Presentation Abstract

Session: Poster Session B Presentations and Light Lunch
Abstract Number: 765
Title: Serosurvey of dengue, Zika and other mosquito-borne viruses in French Polynesia
Presentation Start: 10/27/2015 12:00:00 PM
Presentation End: 10/27/2015 1:45:00 PM
Authors: Maite Aubry1, Anita Teissier1, Claudine Roche1, Sylviane Teururai1, Sylvie Paulous2, Philippe Desprès2, Henri-pierre Mallet3, Sébastien Merceron4, Michael Huart5, Sébastien Sicard5, Xavier Deparis5, Didier Musso1, Van-Mai Cao-Lormeau1
1Institut Louis Malardé, Papeete, French Polynesia, 2Institut Pasteur, Paris, France, 3Direction de la Santé de la Polynésie française, Papeete, French Polynesia, 4Institut de la Statistique de la Polynésie française, Papeete, French Polynesia, 5Université Aix-Marseille, Marseille, France
Abstract: Since the 40s, dengue virus (DENV) has been the only mosquito-borne virus actually considered as major public health concern in the Pacific region and more particularly in French Polynesia (FP). In 2013, Zika virus (ZIKV) was detected in FP for the first time and caused the largest outbreak ever reported. In order to anticipate the possible burden of arthropod-borne viruses (arboviruses), we conducted a serosurvey intended to identify the viruses the French Polynesian population is mostly immunologically naïve for or has already been exposed to. During the first semester of 2014, serum samples were collected from 196 participants aged 7-86 years (median 41 years) living in the most inhabited islands of the five archipelagoes of FP, and from 476 school children aged 6-16 years (median 11 years) living on the main island, Tahiti. Serum samples were tested for the presence of specific IgGs against the four different DENV serotypes, ZIKV, Chikungunya virus (CHIKV), Japanese encephalitis virus (JEV), West Nile virus (WNV) and Ross River virus (RRV). Seropositivity rates found among residents and school children were respectively 88% and 50% for DENV-1, 51% and 0% for DENV-2, 67% and 15% for DENV-3, 61% and 15% for DENV-4, 50% and 66% for ZIKV, 3% and 1% for CHIKV, 10% and 1% for JEV, 8% and 3% for WNV, and 35% and 1% for RRV. The level and distribution by age of the seropositivity for the different DENV serotypes is overall consistent with epidemiological data. Most notably, the lower level of seropositivity for DENV-2 compared to the other 3 serotypes may be associated with a higher risk of re-emergence of this serotype in FP. At least half of the residents and children have ZIKV IgGs, showing that most people were immunized during the 2013 epidemic. The results also suggest that RRV may have circulated in FP although it has never been reported. The low level of immunization (10% or less) against CHIKV, WNV and JEV may be associated with a high risk of emergence of these viruses in FP, as confirmed by the occurrence of a large CHIKV outbreak that started in FP in October 2014.




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