Session Detail


Session Number: 547
Session Title: Retina/RPE Biochemistry and Molecular Biology
Session Type: Poster Session
Session Start: Thursday, May 06, 2010, 11:15 AM - 1:00 PM
Location: Hall B/C
Organizing Section: Biochemistry/Molecular Biology
Program #/Board #: 5951-5982/A172-A203
Moderator-- P.C. Kothary. Ophthalmology, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, MI.
Presentations:
Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5951/ A172. Effect of Unique Retinal Environment on Catalytic Properties of Cholesterol-Metabolizing P450s
G. Heo1, N. Mast1, I.A. Pikuleva1, W.-L. Liao2, I.V. Turko2. 1Ophthalmology&Visual Science, Case Western Reserve University, Cleveland, OH; 2Center for Advanced Research in Biotechnology, NIST/UMBI, Rockville, MD.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5952/ A173. Global Target Analysis of Nrl, the Key Transcriptional Regulator of Photoreceptor Differentiation and Homeostasis
H. Hao1, D.S. Kim1, K. Johnson2, C. Zang3, K. Cui3, J. Gregorski1, F. Yang2, K. Zhao3, A. Swaroop1. 1Neurobiol, Neurodegnrtn & Rpr Lab, National Eye Institute, Bethesda, MD; 2Division of Intramural Research, NINDS/NIH, Bethesda, MD; 3Laboratory of Molecular Immunology, NHLBI/NIH, Bethesda, MD.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5953/ A174. Continuous Fluorescent Lamp Illumination Enhances Apoptosis by Indocyanine Green on Cultured Human Retinal Pigment Epithelial Cells
T. Sato1, M. Ito2A, M. Ishida2B, Y. Karasawa2B. 1Division of Pediatric Ophthalmology and Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; ADepartment of Developmental Anatomy and Regenerative Biology, BOphthalmology, 2National Defense Medical College, Tokorozawa, Japan.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5954/ A175. A New HPLC-ESI-MS/MS Method to Characterize and Quantify Phosphatidyl-Choline With VLC-PUFA: Application to Human Retina
O. Berdeaux1,2, L. Martine1, S. Cabaret1,2, G. Thuret3, S. Gregoire1, P. Gain3, C.P. Garcher4,1, A.M. Bron4,1, N. Acar1, L. Bretillon1. 1INRA, University of Burgundy, Eye & Nutrition Research Group, Dijon, France; 2INRA, University of Burgundy, Lipid-Aroma Platform, Dijon, France; 3University Hospital, Biology, Engineering and Imaging of Corneal Grafts, JE2521, University Jean Monnet, Saint Etienne, France; 4Ophthalmology, University Hospital, Dijon, France.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5955/ A176. Effect of Insulin Like Growth Factor-1 on Vascular Endothelial Growth Factor Receptor-2 in Human Retinal Pigment Epithelial Cells
P.C. Kothary, P. Lee, M.A. Del Monte. Ophthalmology, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, MI.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5956/ A177. Transgenic Mice Overexpressing Mutant βA3/A1-Crystallin in Astrocytes Show Abnormalities in Retinal Pigment Epithelial (RPE) Cells With Increasing Age
B.L. Patek1, R. Grebe1, G.A. Lutty1, J.S. Zigler, Jr.1, E.F. Wawrousek2, D. Sinha1. 1Wilmer Eye Institute, Baltimore, MD; 2Lab of Molecular & Dev Bio, National Eye Inst/NIH, Rockville, MD.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5957/ A178. Role of AMP-Dependent Kinase in the Function of Retinal Pigment Epithelium
A. Thanos, Y. Morizane, G. Trichonas, T.D. Papakostas, L.H. Young, D. Vavvas. Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, MA.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5958/ A179. Role of Fat Protocadherins in Early Eye Development & Optic Fissure Closure
S. Bharti1, I.F. Onojafe1, J.D. Brown1, H. McNeill2, B.P. Brooks1. 1NEI/NIH, Bethesda, MD; 2Molecular Genetics, Mount Sinai Hospital, University of Toronto, ON, Canada.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5959/ A180. Compositional Analyses and Age-Related Changes of High Molecular Weight Gelatinases of Human Bruch’s Membrane and Their Changes After Exposure to EGTA
Y. Lee1, A.A. Hussain2, J. Marshall3. 1Department of Ophthalmology, King's College London, Lambeth Palace Road, London, United Kingdom; 2Ophthalmology, St Thomas Hosp, Rayne Institute, London, United Kingdom; 3UCL, Farnborough, United Kingdom.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5960/ A181. Extended Glutamine Tract Protein Expression in Rpe Cells Induces Proteotoxic-Stress and Apoptosis That Is Prevented by Neuroprotectin D1
J.M. Calandria1A, P. Mukherjee1A, N.G. Bazan1B. ANeuroscience Center, BOphthal & Neuroscience, 1LSU Health Sciences Center, New Orleans, LA.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5961/ A182. Lipid Peroxidation Products--A New Activator of the Canonical Wnt Pathway
T. Zhou1, K. Zhou1, G. Gao2, J. Ma1. 1Cell Biology, Oklahoma Univ Health Science Ctr, Oklahoma City, OK; 2Cell Biology, Zhongshan Medical School , Sun Yat-sen University, Guangzhou, China.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5962/ A183. Epidermal Growth Factor, a Potent Initiator of RPE Cell Proliferation
K. Steindl1, M.E. Boulton2, W. Krugluger3, P. Haas4A, A. Dossenbach-Glaninger4B, S. Binder4A. 1Ludwig Boltzmann Institute for Retinology & Biomicroscopic Lasersurgery, Department of Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria; 2Department of Anatomy and Cell Biology, University of Florida, Florida, FL; 3Department of Clinical Chemistry, Donauspital, Vienna, Austria; AOphthalmology, BDepartment of Clinical Chemistry, 4Rudolf Foundation Clinic, Vienna, Austria.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5963/ A184. Arrestin Domain-Containing Proteins Are Expressed in Multiple Regions of the Mammalian Retina
R.P. Gross, S. Bolch, D.R. Dugger, J. Li, W.C. Smith. Ophthalmology, University of Florida, Gainesville, FL.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5964/ A185. Imaging System for Oxygen Saturation and Blood Flow Measurement in the Retina
J.C. Ramella-Roman1, P. Lemaillet1, D. Duncan2, M. Ibrahim3, Q. Nguyen3. 1Biomedical Engineering, Catholic University of America, Washington, DC; 2Biomedical Engineering, Oregon Health & Science University, Portland, OR; 3Johns Hopkins Wilmer Eye Inst, Baltimore, MD.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5965/ A186. Smad3 Regulate NET1, Rho GEF, in TGF-β Induced Human RPE
J. Lee1, H.-J. Moon1, C.-K. Joo2. 1Ophthalmology & Visual Science, Catholic University of Korea, Seoul, Republic of Korea; 2Ophthalmology & Visual Sci, Catholic Univ Korea Coll of Med, Seoul, Republic of Korea.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5966/ A187. Expression Profiling of Nuclear Receptors in Human Retinal Pigment Epithelial Cells: Relevance to Age-Related Macular Degeneration
G. Malek1A, P. Hu2, M. Dwyer1B, S.W. Cousins1C, D.P. McDonnell1B. AOphthalmology and Pathology, BPharmacology and Cancer Biology, COphthalmology, 1Duke University, Durham, NC; 2Ophthalmology, Duke University Eye Center, Durham, NC.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5967/ A188. Mutual Inhibition of Norrin and TGF-ß Signaling in vitro and in vivo
A. Ohlmann, R. Seitz, E.R. Tamm. Inst. of Anatomy, University of Regensburg, Regensburg, Germany.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5968/ A189. Decreased Retinal Function in Immunoproteasome-Deficient Mice
S.A. Hussong1A, R.J. Kapphahn1A, H. Roehrich1B, M. Maldonado1A, M.T. Pardue2,3, D.A. Ferrington1A. AOphthalmology, BHistology Core for Vision Research, 1Univ of Minnesota, Minneapolis, MN; 2Rehab R&D Center, Atlanta VA Medical Center, Decatur, GA; 3Ophthalmology, Emory University School of Medicine, Atlanta, GA.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5969/ A190. Biochemical and Cellular Events Associated With Retinal Detachment
A.S. Solomon1, O. Klebanov1, A. Nitzan2, A. Barzilai3. 1Goldschleger Eye Research, Tel-Aviv University, Tel-Hashomer, Israel; 2Life Science Faculty, Tel-Aviv University, Tel Aviv, Israel; 3Life Science Faculty, Tel-Aviv University, Tel- Aviv, Israel.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5970/ A191. Caveolin-1 Regulates Na+/K+-ATPase Activity in the Retinal Pigment Epithelium
M.H. Elliott1,2, M.E. McClellan1,2, M.N.A. Mandal1,2, J.D. Ash1,2, B. Nagel3, J. Ryerse3, S.J. Fliesler4. 1Ophthalmology, Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, OK; 2Dean A McGee Eye Institute, Oklahoma City, OK; 3Dept of Pathology, St Louis Univ Hlth Sci Ctr, St Louis, MO; 4Ophthalmology, SUNY-Buffalo Ophthal/VA Medical Ctr, Buffalo, NY.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5971/ A192. Regulation of Rhodopsin Expression: Identification of Rhodopsin Enhanceosome Components From Bovine Retina
S.P. Yadav, J. Nellissery, A. Swaroop. Neurobiology, Neurodegenera & Repair Lab, National Eye Institute, Bethesda, MD.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5972/ A193. The STAT Protein Inhibitor, AG 490, Inhibits Erythropoietin Production in Human Retinal Pigment Epithelial Cells
J. Badhwar, P.C. Kothary, PhD, M.A. Del Monte, MD. Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, MI.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5973/ A194. Von Hippel-Lindau Expression in the Retinal Pigment Epithelium is Essential for Normal Eye Development and Vascular Homeostasis
C.A. Lange1, F.M. Mowat1, U.F.O. Luhmann1, A.J. Smith1, P.H. Maxwell2, R.R. Ali1, J.W. Bainbridge1. 1Department of Genetics, Institute of Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology, London, United Kingdom; 2Division of Medicine, The Rayne Institute, UCL, London, United Kingdom.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5974/ A195. A New Strategy to Identify and Annotate Human RPE-Specific Gene Expression
A.A.B. Bergen1,2, J.B. ten Brink1, S.M. Swagemakers3, A.J. Verkerk3, A. Essing1, P.J. van der Spek3, T.G. Gorgels1, J.C. Booij1. 1Molecular Ophthalmogenetics, Netherlands Inst for Neuroscience, Amsterdam, The Netherlands; 2Clinical Genetics and Ophthalmology, AMC, Amsterdam, The Netherlands; 3Bioinformatics, EMC, Rotterdam, The Netherlands.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5975/ A196. Fibroblast Growth Factor Causes Cyclooxygenase to Produce Reactive Oxygen Species Which Modulate Survival Pathways in Retinal Cell Lines
S.M.J. Farrell1,2, G. Groeger2, D. Wallace1, C.J. O'Brien1, T.G. Cotter2. 1Dept of Ophthalmology, Mater Misericordiae University Hospital, Dublin 7, Ireland; 2Dept of Biochemistry, University College Cork, Cork, Ireland.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5976/ A197. Specific Interaction of the OA1 GPCR With the Gαi3 Protein
A. Young, M. Jiang, N.B. Akhmedov, D.B. Farber. Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5977/ A198. Loss of Melanoregulin (MREG) May Function as a Possible Risk Factor for Retinal Degenerative Diseases
A.S. Kazi, R. Dierova, J. Brancato, A. Bragin, K. Boesze-Battaglia. Biochemistry/Sch of Dental Med, Univ of Pennsylvania, Philadelphia, PA.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5978/ A199. Would Circulating Cholesteryl Esters be Considered as Markers for Fatty Acid Composition of the Human Retina ?
L. Bretillon1, N. Acar1, S. Gregoire1, G. Thuret2, A.M. Bron3,1, P. Gain2, C. Creuzot-Garcher3,1. 1INRA, University of Burgundy, Eye & Nutrition Research Group, Dijon, France; 2University Hospital, Biology, Engineering and Imaging of Corneal Grafts, JE2521, University Jean Monnet, Saint Etienne, France; 3Ophthalmology, University Hospital, Dijon, France.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5979/ A200. Dose-Dependent Differential Effect of HDAC Inhibitors on Yields of Folded P23H and WT Rhodopsin
S.M. Noorwez1, S. Kaushal2. 1Ophthalmology, University of Massachusetts Medical School, Worcester, MA; 2Ophthalmology, UMass Memorial Medical Center, Worcester, MA.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5980/ A201. Role of Heat Shock Response in Rhodopsin Folding
R. Sama1, S.M. Noorwez1, S. Kaushal2. 1Ophthalmology, UMASS Medical School, Worcester, MA; 2Ophthalmology, UMass Memorial Medical Center, Worcester, MA.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5981/ A202. Lipid and Apolipoprotein Blood Levels in Patients With Retinal Vein Occlusion
W. Buehl1, E.-M. Reitter1, T. Stojakovic2, H. Scharnagl2, R. Dunavoelgyi1, G. Matt1, S. Sacu1, U. Schmidt-Erfurth1. 1Dept. of Ophthalmology, Medical University of Vienna, Vienna, Austria; 2Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

Thursday, May 06, 2010, 11:15 AM - 1:00 PM
5982/ A203. Withdrawn

 



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