Presentation Abstract

Title: P10.41 - Mitochondrial genome diversity in Ulchi, the tungusic-speaking tribe of the Russian Far East
Keywords: mtDNA; Ulchi; haplogroup
Authors: N. Volodko, E. Starikovskaya, R. Sukernik;
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russian Federation.
Abstract Body: The present report is based on the study of mtDNA variation in Ulchi (n=74), a Tungusic-speaking tribe of hunters and fishermen dispersed along the lakes and reaches of the Lower Amur. MtDNA analysis revealed 39 distinct mtDNA haplotypes belonging to 21 Eurasian haplogroups C2-C3, D3-D8, D11, G1-G2, M7-M9, Z, B, F, N9, Y and U4, with overall N macrohaplogroup derivatives frequency 53%, M - 43%, and R - 4%. It is generally accepted, that rapid migration along the Asian Pacific margin brought undifferentiated M as far as Japan and Russian Far East. The regionally differentiated MD, MG and M7 mtDNA lineages were of our special interest in light of the Late Pleistocene migrations of modern humans into circum-Pacific region. One of our major findings is the discovery of M7a2 haplotype with 16140-16187-16209-16223-16519 HVSI motif which is specific for ancient Okhotsk people (Sato et al. 2007). Ancient admixture of East and West Eurasians is also found in the Ulchi population of the Lower Amur region. The presence of such haplogroups as N9 and Y in south-eastern Siberia, with 50% frequency of Y in Ulchi, reflects complex genetic and demographic history, including natural selection and founder effects. The coalescent dates and spatial distribution of N9 and Y across Eurasia let us to suggest that the root mutation 5417 emerged somewhere in Southwestern Asia ~40.0 ka, and its particular derivatives (N9a, N9b, Y) have been involved in the eastward expansion, with the Y lineage (~23 ka) being the most successful at the periphery.