Session Detail


Session Title: Epigenetic Therapy and Risk Biomarkers
Session Type: Poster Session
Session Start/End Time: Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Location: Hall A-E, Poster Section 29
Session Category: Molecular and Cellular Biology 7
Presentations:
671: Identification of potent BET bromodomain inhibitors for treatment of cancer
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Sanjita Sasmal1, Rajeev Kumar Shrimali1, Chandrasekhar Abbineni1, Kamala Kumari Arumalla1, Anirudha Lakshminarasimhan2, Karthikeyan Narasingapuram Arumugam2, Nirbhay Kumar Tiwari1, Narasimha K. Rao2, Aravind AB2, Subramanya Hosahalli2. 1Aurigene Discovery Technologies Ltd, Hyderabad, India; 2Aurigene Discovery Technologies Ltd, Bangalore, India
672: Histone deacetylase inhibition has potential to suppresse growth of androgen dependent and independent prostate cancer in vitro and in vivo
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Shinya Sato, Shugo Suzuki, Aya Naiki-Ito, Yoriko Yamashita, Makoto Asamoto, Tomoyuki Shirai, Satoru Takahashi. Nagoya City University, Nagoya City, Japan
673: Targeting LSD1-HDACs crosstalk as a potential therapeutic strategy for triple negative breast cancer cells
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Shauna Vasilatos, Tiffany A. Katz, Steffi Oesterreich, Nancy E. Davidson, Yi Huang. University of Pittsburgh Cancer Institute, Pittsburgh, PA
674: The lysine demethylase KDM1 is a novel therapeutic target for the treatment of gliomas
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Gangadhara R. Sareddy, Sandeep Saran, Binoj C. Nair, Samaya R. Krishnan, Vijay K. Gonugunta, Andrew J. Brenner, Ratna K. Vadlamudi. UTHSCSA, San Antonio, TX
675: Jarid2 is a novel target for lung cancer therapy
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Young K. Hong, Mary Zhang, Scott Atay, Manish Raiji, Trevor Upham, Julie A. Hong, Mahadev Rao, David S. Schrump. Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD
676: Substrate specificity and inhibitors of histone lysine HMTase NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Eric Di Luccio, Masayo Morishita. Kyungpook National University, Daegu, Korea, Republic of
677: Transient exposure to decitabine results in sustained cell growth inhibition and long term DNA demethylation at specific loci
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Gangning Liang, Han Han, Daniel D. De Carvalho, Xiaojing Yang, Peter A. Jones. USC/Norris Comprehensive Cancer Ctr., Los Angeles, CA
678: Evaluation of oral bioavailability and intermittent dosing schedules for pharmacodynamic effects by SGI-110, a novel subcutaneous (SQ) second generation hypomethylating agent (HMA), in male cynomolgus monkeys
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Aram Oganesian, Pietro Taverna, Mohammad Azab. Astex Pharmaceutical, Inc., Dublin, CA
679: SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Carmen S. Tellez1, Marcie J. Grimes1, Maria A. Picchi1, Yushi Liu1, Tom H. March1, Aram Oganesian2, Pietro Taverna2, Steven A. Belinsky1. 1Lovelace Respiratory Research Inst., Albuquerque, NM; 2Astex Pharmaceuticals, Inc., Dublin, CA
680: In vivo immunomodulatory activity of SGI-110, a second generation hypomethylating agent, in hematologic malignancies
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Alessia Covre1, Giulia Parisi1, Hugues Jmg Nicolay1, Ester Fonsatti1, Elisabetta Fratta2, Luca Sigalotti2, Pietro Taverna3, Sandra Coral2, Michele Maio1. 1University Hospital of Siena, Siena, Italy; 2IRCCS Centro di Riferimento Oncologico, Aviano, Italy; 3Astex Pharmaceuticals Inc, Dublin, CA
681: SGI-110, a novel 5-aza-2’-deoxycytidine- containing dinucleotide, induces Cancer Germline (CG) antigen expression in Acute Myeloid Leukemia (AML) cells
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Elizabeth A. Griffiths1, Pragya Srivastava1, Golda Collamat-Lai1, Smitha R. James1, Adam R. Karpf2. 1Roswell Park Cancer Institute, Buffalo, NY; 2Eppley Institute for Cancer Research, Omaha, NE
682: Synergistic effects of CG200745 combining with Gemcitabine and/or Erotinib in pancreatic cancer
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Seonggu Ro, Jang-Won Hong, Sool-Ki Kwon, Hyunju Cha, Dong Sub Jung, Ho-Jin Chang, Joong Myung Cho. Crystal Genomics, Seongnam, Korea, Republic of
683: Toxicity of aerosolized azacytidine (Vidaza) in mice
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Xuan Qiu1, Rani Sellers2, Yuanxin Liang1, Bilal Piperdi1, Roman Perez-Soler1, Yiyu Zou1. 1Albert Einstein College of Medicine, Cancer Ctr., Bronx, NY; 2Albert Einstein College of Medicine, Pathology, Bronx, NY
684: Novel potent curcumin analogues EF-31 and UBS109 inhibit DNA methylation and induce SPARC expression in pancreatic cancer
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Purnachandra Nagaraju Ganji, Shijun Zhu, Shoji Mamoru, Bassel El-Rayes. Emory Univ., Atlanta, GA
685: Epigenetic modulators and calcium-sensing receptor expression in colorectal cancer cells
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Irfete Sh. Fetahu, Julia Höbaus, Abhishek Aggarwal, Samawansha Tennakoon, Ildiko Mesteri, Sabina Baumgartner-Parzer, Enikoe Kallay. Medical University of Vienna, Vienna, Austria
686: LINE-1 %5-Methylcytosine levels in pre-diagnostic leukocyte DNA and subsequent renal cell cancer risk
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Sara Karami1, Gabriella Andreotti1, Ruth M. Pfeiffer1, Linda M. Liao1, Stephanie Weinstein1, Demetrius Albanes1, Jarmo Virtamo2, Nathaniel Rothman1, Lee E. Moore1. 1National Cancer Institute, Rockville, MD; 2National Institute for Health and Welfare, Helsinki, Finland
687: Variations in promoter methylation levels of DNA repair genes and breast cancer risk in the New York site of the Breast Cancer Family Registry
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Maya A. Kappil, Mary Beth Terry, Yuyan Liao, Regina Santella. Columbia Univ. Medical Ctr., New York, NY
688: Promoter methylation of death receptor decoy genes in blood and risk of melanoma in melanoma-prone families
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Paula L. Hyland, Laura S. Burke, Ruth M. Pfeiffer, Margaret A. Tucker, Alisa M. Goldstein, Xiaohong R. Yang. Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD
689: Methylation of miRNA genes is a useful biomarker for detection of bladder cancer
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Hiromu Suzuki, Takashi Shimizu, Masanori Nojima, Eiichiro Yamamoto, Reo Maruyama. Sapporo Medical University, Sapporo, Japan
690: Potential biomarkers for the prediction of urothelial cell carcinoma recurrence
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Christina Michailidi1, Leonel Maldonado1, Mariana Brait1, Luciana Schultz2, Jong Chul Park1, David Sidransky1, George Netto2, Mohammad O. Hoque1. 1The Johns Hopkins University, School of Medicine, Department of Otolaryngology and Head and Neck Surgery, Baltimore, MD; 2The Johns Hopkins University, School of Medicine, Department of Pathology, Baltimore, MD
691: Methylation of APC and GSTP1 in non-neoplastic tissue adjacent to prostate tumour and mortality from prostate cancer
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
Chiara Celestina Grasso1, Lorenzo Richiardi1, Valentina Fiano1, Daniela Zugna1, Anna Gillio Tos1, Luisa Delsedime2, Franco Merletti1. 1University of Turin, Turin, Italy; 2Unit of Pathology, Molinette Hospital, Turin, Italy
692: Histone deacetylase 11 is an epigenetic regulator of CD8+ T-cell effector function and memory formation
Sunday, Apr 07, 2013, 1:00 PM - 5:00 PM
David M. Woods1, Karrune Woan2, Fengdong Cheng3, Hong Wei Wang3, Eva Sahakian3, John Powers3, Jennifer Rock-Klotz3, Alejandro Villagra3, Javier Pinilla-Ibarz3, Eduardo Sotomayor3. 1University of South Florida College of Medicine, Tampa, FL; 2University of Florida, Gainesville, FL; 3Moffitt Cancer Center, Tampa, FL