Session Detail


Session Title: Pediatric Cancer 1: Genomic Landscapes, Microenvironment, and Response to Therapy
Session Type: Minisymposium
Session Start/End Time: Tuesday, Apr 09, 2013, 3:00 PM - 5:00 PM
Location: Salon C, East Hall, Washington Convention Center
CME: CME-Designated
CME/CE Hours: 2
Session Category: Tumor Biology 45
Presentations:
Chairperson
Tuesday, Apr 09, 2013, 3:00 PM - 5:00 PM
Alejandro Sweet-Cordero. Stanford Univ. School of Medicine, Stanford, CA
Chairperson
Tuesday, Apr 09, 2013, 3:00 PM - 5:00 PM
Adolfo Ferrando. Columbia Univ., New York, NY
Introduction

Tuesday, Apr 09, 2013, 3:00 PM - 3:05 PM
4591: Whole genome sequencing of SHH medulloblastomas predicts molecular groups of responders and non-responders to SMO-inhibition
Tuesday, Apr 09, 2013, 3:05 PM - 3:20 PM
Marcel Kool1, David TW Jones1, Natalie Jaeger1, Paul A. Northcott1, Volker Hovestadt1, Ulrich Schueller2, Marc Remke3, Yoon-Jae Cho4, Scott Pomeroy5, Michael D. Taylor3, Roland Eils1, Andrey Korshunov1, Peter Lichter1, Stefan M. Pfister1. 1German Cancer Research Ctr., Heidelberg, Germany; 2Center of Neuropathology, Ludwig-Maximilians University, Munich, Germany; 3Hospital for Sick Children, Toronto, ON, Canada; 4Stanford University School of Medicine, Stanford, CA; 5Children's Hospital and Harvard Medical School, Boston, MA
4592: Exome sequencing of hepatoblastoma reveals recurrent mutations in NFE2L2
Tuesday, Apr 09, 2013, 3:20 PM - 3:35 PM
Lisa R. Trevino1, David A. Wheeler1, Milton J. Finegold1, Murali Chintagumpala1, Kayuri U. Patel1, Stephen F. Sarabia1, Sarah A. Comerford2, Robert E. Hammer2, Dinesh Rakheja2, Rebecka L. Meyers3, Yidong Chen4, Bradley H. Pollock4, Gail E. Tomlinson4, Dolores H. López-Terrada1, D. Williams Parsons1. 1Baylor College of Medicine and Texas Children's Hospital, Houston, TX; 2University of Texas Southwestern Medical Center, Dallas, TX; 3University of Utah, Primary Children’s Medical Center, Salt Lake City, UT; 4University of Texas Health Science Center at San Antonio, San Antonio, TX
4593: Genome-wide association study identifies novel loci associated with osteosarcoma
Tuesday, Apr 09, 2013, 3:35 PM - 3:50 PM
Sharon A. Savage1, Lisa Mirabello1, Zhaoming Wang2, Julie Gastier-Foster3, Richard Gorlick4, Chand Khanna5, Adrienne M. Flanagan6, Roberto Tirabosco7, Irene L. Andrulis8, Jay Wunder8, Nalan Gokgoz8, Ana Patino-Garcia9, Luis Sierrasesumaga9, Fernando Lecanda9, Nilgun Kurucu10, Inci Ergurhan Ilhan10, Neriman Sari10, Massimo Serra11, Claudia Hattinger11, Piero Picci11, Logan Spector12, Donald A. Barkauskas13, Neyssa Marina14, Siliva Caminada de Toledo15, Sergio Petrilli15, Maria Fernanda Amary7, Dina Halai7, David Thomas16, Chester Douglass17, Paul Meltzer5, Kevin Jacobs2, Charles C. Chung1, Sonja I. Berndt1, Mark P. Purdue1, Neil E. Caporaso1, Margaret Tucker1, Nathaniel Rothman1, Maria Teresa Landi1, Debra T. Silverman1, Peter Kraft17, David J. Hunter17, Nuria Malats18, Manolis Kogevinas19, Sholom Wacholder1, Rebecca Troisi1, Lee Helman5, Joseph F. Fraumeni, Jr.1, Meredith Yeager2, Robert Hoover1, Stephen J. Chanock1. 1National Cancer Institute, Rockville, MD; 2SAIC-Frederick, Inc, NCI-Frederick, Frederick, MD; 3Nationwide Children's Hospital, Columbus, OH; 4Albert Einstein College of Medicine, Bronx, NY; 5National Cancer Institute - CCR, Bethesda, MD; 6UCL Cancer Institute and Royal National Orthopaedic Hospital NHS Trust, Manchester, United Kingdom; 7Royal National Orthopaedic Hospital NHS Trust, Manchester, United Kingdom; 8University of Toronto, Toronto, ON, Canada; 9Universidad De Navarra, Pamplona, Spain; 10A.Y. Ankara Oncology Training and Research Hospital, Ankara, Turkey; 11Orthopaedic Rizzoli Institute, Bologna, Italy; 12University of Minnesota, Minneapolis, MN; 13Keck School of Medicine, University of Southern California, Los Angeles, CA; 14Stanford University & Lucile Packard Children's Hospital, Palo Alto, CA; 15GRAACC/UNIFESP, Sao Paulo, Brazil; 16University of Melbourne, Melbourne, Australia; 17Harvard School of Public Health, Boston, MA; 18Centro Nacional de Investigaciones Oncologicas, Madrid, Spain; 19Centre for Research in Environmental Epidemiology, Barcelona, Spain
4594: Recurrent FGFR1 hotspot mutations represent a novel therapeutic target in childhood astrocytoma
Tuesday, Apr 09, 2013, 3:50 PM - 4:05 PM
David TW Jones1, Barbara Hutter1, Natalie Jäger1, Andrey Korshunov2, Marcel Kool1, Sally R. Lambert3, Dong Anh Khuong Quang4, Adam M. Fontebasso4, Marina Ryzhova5, Hans-Jörg Warnatz6, Thomas Zichner7, Jan O. Korbel7, Stephan Wolf1, Marie-Laure Yaspo6, Keith L. Ligon8, Mark W. Kieran8, Benedikt Brors1, Jörg Felsberg9, Guido Reifenberger9, V. Peter Collins3, Nada Jabado4, Roland Eils1, Peter Lichter1, Stefan M. Pfister1, ICGC PedBrain Tumor Project. 1German Cancer Research Center, Heidelberg, Germany; 2University of Heidelberg, Heidelberg, Germany; 3University of Cambridge, Cambridge, United Kingdom; 4McGill University Health Center Research Institute, Montreal, QC, Canada; 5Burdenko Neurosurgical Institute, Moscow, Russian Federation; 6Max Planck Institute for Molecular Genetics, Berlin, Germany; 7European Molecular Biology Laboratory, Heidelberg, Germany; 8Dana Farber Cancer Institute, Boston, MA; 9Heinrich Heine University Düsseldorf, Düsseldorf, Germany
4595: Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL
Tuesday, Apr 09, 2013, 4:05 PM - 4:20 PM
Gannie Tzoneva1, Arianne Perez-Garcia1, Zachary Carpenter1, Hossein Khiabanian1, Valeria Tosello1, Maddalena Allegretta1, Elisabeth Paietta2, Janis Racevkis2, Jakob M. Rowe3, Martin S. Tallman4, Maddalena Paganin5, Jana Hoff6, Renate Kirschner-Schwabe6, Teresa Palomero1, Raul Rabadan1, Adolfo Ferrando1. 1Columbia Univ., New York, NY; 2Albert Einstein College of Medicine, New York, NY; 3Ramban Medical Center, Haifa, Israel; 4Memorial Sloan Kettering Cancer Center, New York, NY; 5University of Padua, Padua, Italy; 6Charité-Universitätsmedizin Berlin, Berlin, Germany
4596: LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling
Tuesday, Apr 09, 2013, 4:20 PM - 4:35 PM
Johannes H. Schulte1, Jan Molenaar2, Sven Lindner1, Alexander Schramm1, Pieter Mestdagh3, Frank Speleman3, Rogier Versteeg2, Angelika Eggert1. 1Univ. Children's Hospital, Essen, Germany; 2Dept. of Oncogenomics, Academic Medical Center, Amsterdam, Netherlands; 3Center for Medical Genetics, Ghent University, Gent, Belgium, Belgium
4597: Stroma-derived Basigin controls survival of leukemia cells through regulation of their redox state
Tuesday, Apr 09, 2013, 4:35 PM - 4:50 PM
Beat C. Bornhauser1, Jeannette Boutter1, Peter Horvath2, Martin Stanulla3, Jean-Pierre Bourquin1. 1Univ. Children's Hospital Zurich, Zurich, Switzerland; 2Light Microscopy and Screening Centre, ETH Zürich, Zurich, Switzerland; 3University Hospital Schleswig-Holstein, Kiel, Germany
Discussion

Tuesday, Apr 09, 2013, 4:50 PM - 5:00 PM