Session Detail


Session Title: GWAS, Post-GWAS, and Functional Studies
Session Type: Poster Session
Session Start/End Time: Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Location: Hall A-E, Poster Section 10
Session Category: Epidemiology 6
Presentations:
2542: Evidence for large somatic structural events detected as autosomal genetic mosaicism in GWAS data
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Mitchell J. Machiela1, Weiyin Zhou2, Meredith Yeager2, Kevin Jacobs2, Sonja Berndt1, Qing Lan1, Nathaniel Rothman1, Sharon Savage1, Phil R. Taylor1, Immaculata deVivo3, National Cancer Institute Detectable Clonal Mosaicism Consortium, Robert N. Hoover1, Margaret A. Tucker1, Stephen J. Chanock1. 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD; 2Cancer Genomics Research, SAIC-Frederick, Inc, NCI-Frederick, Frederick, MD; 3Department of Epidemiology, Harvard School of Public Health, Boston, MA
2543: A genome-wide analysis of ROHs identifies two susceptibility regions for non-cardia gastric cancer in han Chinese
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Zhibin Hu1, Cheng Wang1, Guangfu Jin1, Dongxin Lin2, Hongbing Shen1. 1Nanjing Medical Univ., Nanjing, China; 2Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2544: Potential gene variants associated with obesity following cranial radiation treatment for childhood cancer in a genome-wide association study
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Carmen L. Wilson, Wei Liu, Geoffrey Neale, Deokumar Srivastava, James G. Gurney, Guolian Kang, Perdeep Mehta, Rohit Ojha, Melissa M. Hudson, Leslie L. Robison, Kirsten K. Ness. St. Jude Children's Hospital, Memphis, TN
2545: Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in Chinese
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Hongbing Shen1, Jing Dong1, Guangfu Jin1, Minjie Chu1, Dongxin Lin2, Zhinbin Hu1. 1Nanjing Medical Univ., Nanjing, China; 2Chinese Academy of Medical Sciences and Peking Union Medical College, China
2546: Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Zsofia Kote-Jarai1, Edward Saunders1, Daniel Leongamornlert1, Malgorzata Tymrakiewicz1, Tokhir Dadaev1, Sarah Jugurnauth1, Sara Benlloch2, Ali Amin Al Olama2, Helen Ross-Adams3, David Neal2, The UKGPCS Collaborators and The PRACTICAL Consortium, Douglas Easton2, Rosalind Eeles1. 1The Institute of Cancer Research, Sutton, United Kingdom; 2University of Cambridge, Cambridge, United Kingdom; 3CRI, Cambridge, United Kingdom
2547: Targeted sequencing of 5p15 locus defined by non-small cell lung cancer (NSCLC) GWAS using next-generation sequencing
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Zhaoxi Wang, Yang Zhao, Li Su, Seunggeun Lee, Xihong Lin, David C. Christiani. Harvard School of Public Health, Boston, MA
2548: Targeted sequencing to identify rare variants in colorectal cancer
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Melissa S. DeRycke, Shanaka R. Gunawardena, Sumit Middha, Shannon K. McDonnell, Shaun M. Riska, Zachary C. Fogarty, Bruce W. Eckloff, Daniel J. Schaid, Ellen L. Goode, Stephen N. Thibodeau. Mayo Clinic, Rochester, MN
2549: A genome-wide association study identifies PSCA as a susceptibility locus for gastric cancer and duodenal ulcer in the Japanese population
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Chizu Tanikawa, Koichi Matsuda, Yusuke Nakamura. Univ. of Tokyo Inst. of Medical Science, Tokyo, Japan
2550: A genome-wide association study of breast cancer survival according to molecular subtype in Korean women
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Nan Song1, Ji-Yeob Choi2, Hyuna Sung2, Keun-Young Yoo3, Wonshik Han4, Dong-Young Noh4, Sei-Hyun Ahn5, Daehee Kang1. 1Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of; 2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea, Republic of; 3Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of; 4Department of Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of; 5University of Ulsan College of Medicine and ASAN Medical Center, Seoul, Korea, Republic of
2551: A genome-wide association study of HCV induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at MHC region
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Matsuda Koichi, Chizu Tanikawa, Yusuke Nakamura. University of Tokyo, Tokyo, Japan
2552: A genome-wide association study of prostate cancer in West African men
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Michael B. Cook1, Zhaoming Wang1, Edward D. Yeboah2, Andrew A. Adjei2, Yao Tettey2, Richard B. Biritwum2, Evelyn Tay2, Ann Truelove3, Shelley Niwa3, Lisa Chu4, Meredith Yeager1, Amy Hutchinson1, Kai Yu1, Christopher A. Haiman5, African American Prostate Cancer GWAS Consortium, Robert N. Hoover1, Ann Hsing4, Stephen J. Chanock1. 1National Cancer Institute, Rockville, MD; 2University of Ghana Medical School, Accra, Ghana; 3Westat, Rockville, MD; 4Cancer Prevention Institute of California, CA; 5University of Southern California, CA
2553: Characterization of rare germline variants in somatically mutated melanoma genes in melanoma-prone families
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Xiaohong (Rose) Yang, Laura Burke, Kevin Jacobs, Michael Cullen, Joseph Boland, Laurie Burdett, Michael Malasky, Melissa Rotunno, Meredith Yeager, Stephen Chanock, Margaret Tucker, Alisa Goldstein. NCI/NIH/DHHS, Bethesda, MD
2554: Constitutive short telomere length and lung cancer risk: a large case- control study
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Beatriz Sanchez-Espiridion, Jian Gu, David W. Chang, Joe Y. Chang, Charles Lu, Jack A. Roth, Xifeng Wu. The University of Texas MD Anderson Cancer Center, Houston, TX
2555: Tissue-specific regulation of alternative splicing by breast cancer associated genetic variants identified in recent GWAS
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Erin K. Wagner, Swapnil Kanifnath Shevate, Yunlong Liu, Chunyan He. Indiana University, Indianapolis, IN
2556: Functional characterization of the pancreatic cancer TERT-CLPTM1L risk locus on chr5p15.33
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Jinping Jia1, Irene Collins1, Marta Dzyadyk1, Abbey Thompson1, Adam Cheuk2, Hemang Parikh1, Zhaoming Wang3, Chris Westlake4, Allen Bosley5, Gloria Petersen6, Thorkell Andresson5, Laufey Amundadottir1. 1NCI-DCEG-LTG, Gaithersburg, MD; 2NCI-pediatric onology branch, Gaithersburg, MD; 3NCI-Frederick-CGR, Gaithersburg, MD; 4NCI-CCR-LCDS, Frederick, MD; 5NCI-Laboratory of proteimics and Analytical Technologies, Frederick, MD; 6Department of Health Sciences Reserch, Rochester, MN
2557: Genetic variants in microRNA genes and breast cancer risk
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Alicia C. Beeghly-Fadiel1, Hyuna Sung2, Ben Zhang1, Ji-Yeob Choi2, Ryan J. Delahanty1, Jirong Long1, Yu-Tang Gao3, Wei Lu4, Qiuyin Cai1, Xiao Ou Shu1, Daehee King2, Wei Zheng1. 1Vanderbilt University, Nashville, TN; 2Seoul National University College of Medicine, Seoul, Korea, Republic of; 3Shanghai Cancer Institute, Shanghai, China; 4Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
2558: miRNA-related gene variants and prostate cancer aggressiveness and recurrence
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Ernest K. Amankwah, Hui-Yi Lin, Hyun Park, Selina Radlein, Julio Pow-Sang, Ardeshir Hakam, Ya-Yu Tsai, Jong Y. Park. H. Lee Moffitt Cancer Ctr. & Res. Inst., Tampa, FL
2559: Long non-coding RNAs as functional targets of germline genetic variation at ovarian cancer susceptibility loci
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Kate Lawrenson1, Honglin Song2, Janet Lee1, Jonathan Tyrer2, Susan Ramus1, Paul Pharoah2, Simon Gayther1. 1USC, Los Angeles, CA; 2University of Cambridge, Cambridge, United Kingdom
2560: MicroRNA target site polymorphisms and colorectal cancer risk in the Ashkenazi Jewish population
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Stephanie L. Stenzel1, Jeremy Gollub2, Michael Shapero2, Andrea Finn2, Gad Rennert3, Stephen B. Gruber4. 1University of Michigan, Ann Arbor, MI; 2Affymetrix, Incorporated, Santa Clara, CA; 3Clalit Health Services National Cancer Control Center; Department of Community Medicine and Epidemiology, Carmel Medical Center; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; 4Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA
2561: MiRNA-related SNPs and risk of esophageal adenocarcinoma and Barrett’s esophagus: post genome-wide association analysis in the BEACON consortium
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Matthew F. Buas1, Lynn Onstad1, David Levine2, Thomas L. Vaughan1, David C. Whiteman3, BEACON Consortium Investigators. 1Fred Hutchinson Cancer Research Center, Seattle, WA; 2University of Washington, Seattle, WA; 3Queensland Institute of Medical Research, Queensland, Australia
2562: Polymorphisms in microRNA (miRNA) pathways and survival in esophageal cancer (EC) patients
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Lawson Eng1, Olusola O. Faluyi2, Xin Qiu2, Dangxiao Cheng2, Daniel J. Renouf3, Lorin Dodbiba1, Sevtap Savas4, Sharon Marsh5, Jennifer J. Knox2, Gail E. Darling2, Rebecca KS Wong2, Wei Xu2, Geoffrey Liu2, Abul K. Azad2. 1Univ. of Toronto, Toronto, ON, Canada; 2Princess Margaret Hospital, Toronto, ON, Canada; 3University of British Columbia, Vancouver, BC, Canada; 4Memorial University of Newfoundland, St John's, NL, Canada; 5University of Alberta, Edmonton, AB, Canada
2563: Identification and functional characterization of a novel UGT2A1 splice variant: Potential importance in tobacco-related cancer susceptibility
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Ryan T. Bushey, Gang Chen, Philip Lazarus. Penn State Univ. College of Medicine, Hershey, PA
2564: Identification of a novel SPOP missense mutation from targeted next-generation sequencing of men with chromosome 17-q linkage
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Kimberly A. Zuhlke1, Anna M. Johnson1, Scott A. Tomlins1, Nallasivam Palanisamy1, Christiane M. Robbins2, Waibhav A. Tembe2, John D. Carpten2, Ethan M. Lange3, William B. Isaacs4, Kathleen A. Cooney1. 1University of Michigan Medical School, Ann Arbor, MI; 2Translational Genomics Research Institute, Phoenix, AZ; 3University of North Carolina School of Medicine, Chapel Hill, NC; 4The Johns Hopkins University School of Medicine, Baltimore, MD
2565: Functional characterization of genetic variants at 16q12 associated with breast cancer in women of African ancestry
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Yoo-Jeong Han1, Jing Zhang1, Yonglan Zheng1, DeZheng Huo2, Olufunmilayo I. Olopade1. 1Center for Clinical Cancer Genetics and Global Health, Department of Medicine, Chicago, IL; 2Department of Health Studies, University of Chicago, Chicago, IL
2566: Functional studies of HLA SNPs associated with risk of follicular lymphoma
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Christine F. Skibola, Jianqing Zhang, Lucia Conde, Kipp Akers, Jacques Riby, Martyn T. Smith, Fenna CM Sillé. UC Berkeley, Berkeley, CA
2567: Genetic risk stratification for breast cancer based on a polygenic risk score and family history
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Nasim Mavaddat1, Paul Pharoah2, Per Hall3, Douglas Easton1, Montserrat Garcia-Closas4, for the Breast Cancer Association Consortium. 1Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; 2Department of Oncology, University of Cambridge, Cambridge, United Kingdom; 3Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; 4Inst. of Cancer Research, Sutton, United Kingdom
2568: Genetic association of POU5F1B at 8q24 with prostate cancer
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Joan P. Breyer, Jeffrey R. Smith. Vanderbilt Univ. Medical Ctr., Nashville, TN
2569: Evaluation of TGFBR2 gene polymorphisms with TGF-βRII protein expression in breast cancer tissues: results from the Shanghai Breast Cancer Study
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Qingchao Qiu1, Yinghao Su1, Wei Lu2, Ben Zhang1, Ying Zheng2, Xiao Ou Shu1, Wei Zheng1, Qiuyin Cai1. 1Vanderbilt Univ., Nashville, TN; 2Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
2570: An integrated germline analysis platform for comprehensive clinical cancer genomics
Tuesday, Apr 09, 2013, 8:00 AM -12:00 PM
Eliezer M. Van Allen1, Nikhil Wagle1, Adam Keizun2, Gregory Kryukov2, Aaron McKenna3, Franklin Huang1, Elaine Hiller1, Irene Rainville1, Daniel Auclair2, Lauren Ambrogio2, Stacy Gray1, Steven Joffe1, Gad Getz2, Judy Garber1, Levi Garraway1. 1Dana Farber Cancer Inst, Brookline, MA; 2Broad Institute, Cambridge, MA; 3University of Washington, Seattle, WA