Session Detail


Session Title: Novel Mechanisms of Metastasis
Session Type: Major Symposium
Session Start/End Time: Monday, Apr 07, 2014, 1:00 PM - 3:00 PM
Location: Ballroom 20D, San Diego Convention Center
CME: CME-Designated
CME/CE Hours: 2
Session Description: Major cause of death by solid cancer is its metastasis to the vital organs. Metastasis can be subdivided into several elementary processes: local invasion, intravasation, transport to distant organs, extravasation, micrometastasis formation, and colonization. These steps can be achieved by the changes in both the cancer epithelium and in their microenvironments. In contrast to the oncogenic alterations in the primary tumors, however, few key mutations were reported that are specific to and responsible for metastasis. Although many pieces of information have been reported to affect cancer metastasis, we still wait for a more comprehensive picture of the metastatic mechanisms. Here we will have presentations of new progresses in the field of metastasis research, and discuss their relevance to clinical therapies.
Presentations:
Chairperson
Monday, Apr 07, 2014, 1:00 PM - 3:00 PM
Makoto Mark Taketo. Kyoto Univ. Graduate School of Medicine, Kyoto, Japan
SY20-01: Role of Notch signaling in colon cancer invasion and metastasis
Monday, Apr 07, 2014, 1:00 PM - 1:20 PM
Makoto Mark Taketo. Kyoto Univ. Graduate School of Medicine, Kyoto, Japan
Discussion
Monday, Apr 07, 2014, 1:20 PM - 1:25 PM
SY20-02: Insights into mechanisms of breast cancer metastasis
Monday, Apr 07, 2014, 1:25 PM - 1:45 PM
Nancy E. Hynes. Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Discussion
Monday, Apr 07, 2014, 1:45 PM - 1:50 PM
NG03: Genomic characterization of 101 brain metastases and paired primary tumors reveals patterns of clonal evolution and selection of driver mutations
Monday, Apr 07, 2014, 1:50 PM - 2:05 PM
Priscilla K. Brastianos, Scott L. Carter, Sandro Santagata, Amaro Taylor-Weiner, Robert T. Jones, Peleg M. Horowitz, Keith L. Ligon, Joan Seaone, Elena Martinez-Saez, Josep Tabernero, Daniel P. Cahill, Sun-Ha Paek, Ian F. Dunn, Bruce E. Johnson, Toni K. Choueiri, Michael S. Rabin, Eric P. Winer, Nancy U. Lin, Paul Van Hummelen, Anat Stemmer-Rachamimov, Rameen Beroukhim, David L. Louis, Tracy T. Batchelor, Jose Baselga, Gad Getz, William C. Hahn. Massachusetts General Hospital, Boston, MA, Broad Institute, Cambridge, MA, Brigham and Women’s Hospital, Boston, MA, Dana-Farber Cancer Institute, Boston, MA, Brigham and Women’s Hospital, Boston, MA, Vall D'Hebron University Hospital, Barcelona, MA, Massachusetts General Hospital, Boston, MA, Seoul National University College of Medicine, Seoul, Korea, Republic of
Discussion
Monday, Apr 07, 2014, 2:05 PM - 2:10 PM
SY20-03: Nuclear-mitochondrial cross-talk: A key determinant of cancer metastasis
Monday, Apr 07, 2014, 2:10 PM - 2:30 PM
Danny R. Welch, Wen Liu, Kyle P. Feeley, Scott W. Ballinger. Univ. of Kansas Cancer Ctr., Kansas City, KS, Univ. of Kansas Cancer Ctr., Kansas City, KS, UAB, Birmingham, AL
Discussion
Monday, Apr 07, 2014, 2:30 PM - 2:35 PM
SY20-04: Mechanisms of malignant progression
Monday, Apr 07, 2014, 2:35 PM - 2:55 PM
Robert A. Weinberg. MIT Whitehead Inst. for Biomed. Research, Cambridge, MA
Discussion
Monday, Apr 07, 2014, 2:55 PM - 3:00 PM