Session Detail


Session Title: Synthetic Lethality
Session Type: Major Symposium
Session Start/End Time: Wednesday, Apr 09, 2014, 11:00 AM - 1:00 PM
Location: Room 6B, San Diego Convention Center
CME: CME-Designated
CME/CE Hours: 2
Session Description: Treatment of cancer is hampered by a paucity of suitable drug targets. Moreover, single agent therapies are rarely curative for advanced disease. Synthetic lethality holds the promise to deliver both entirely new classes of targets for cancer therapy and it allows for the identification of very effective combination therapies. This session will focus on the use of synthetic lethal genetic screens to accomplish these two goals.
Presentations:
Chairperson
Wednesday, Apr 09, 2014, 11:00 AM - 1:00 PM
René Bernards. Netherlands Cancer Inst., Amsterdam, Netherlands
Synthetic lethality as a tool to find effective combination therapies
Wednesday, Apr 09, 2014, 11:00 AM -11:20 AM
René Bernards. Netherlands Cancer Inst., Amsterdam, Netherlands
Discussion
Wednesday, Apr 09, 2014, 11:20 AM -11:25 AM
Targeting the DNA damage response
Wednesday, Apr 09, 2014, 11:25 AM -11:45 AM
Christopher Lord. Inst. of Cancer Research, London, United Kingdom
Discussion

Wednesday, Apr 09, 2014, 11:45 AM -11:50 AM
NG05: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors
Wednesday, Apr 09, 2014, 11:50 AM -12:05 PM
Brooke M. Emerling, Jonathan B. Hurov, George Poulogiannis, Rayman Choo-Wing, Gerburg M. Wulf, Hye-Seok Shim, Katja A. Lamia, Lucia E. Rameh, Xin Yuan, Andrea Bullock, Gina M. DeNicola, Jiaxi Song, Sabina Signoretti, Lewis C. Cantley. Weill Cornell Medical College, New York, NY, Agios Pharmaceuticals, Cambridge, MA, Beth Israel Deaconess Medical Center, Boston, MA, Weill Cornell Medical College, New York, NY, The Scripps Research Institute, La Jolla, CA, Boston University School of Medicine, Boston, MA, Dana-Farber Cancer Institute, Boston, MA
Discussion
Wednesday, Apr 09, 2014, 12:05 PM -12:10 PM
SY43-03: Screening for triple negative breast cancer vulnerabilities
Wednesday, Apr 09, 2014, 12:10 PM -12:30 PM
Fabio Petrocca, Gabriel Altschuler, Shen Mynn Tan, Marc L. Mendillo, Haoheng Yan, D. Joseph Jerry, Andrew L. Kung, Winston Hide, Tan A. Ince, Judy Lieberman. Harvard Medical School, Boston, MA, Harvard School of Public Health, Boston, MA, The Whitehead Institute for Biomedical Research, Cambridge, MA, University of Massachusetts, Amherst, MA, Dana-Farber Cancer Institute and Children’s Hospital, Boston, MA, University of Miami Miller School of Medicine, Miami, FL, Harvard Medical School, Boston, MA
Discussion
Wednesday, Apr 09, 2014, 12:30 PM -12:35 PM
Synthetic lethal approaches for the treatment of lung cancer
Wednesday, Apr 09, 2014, 12:35 PM -12:55 PM
Trever G. Bivona. UCSF, San Francisco, CA
Discussion
Wednesday, Apr 09, 2014, 12:55 PM -10:00 PM