Presentation Abstract

Program#/Poster#: 132.11/A28
Presentation Title: Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells
Location: Hall F-J
Presentation time: Sunday, Oct 14, 2012, 10:00 AM -11:00 AM
Authors: C. E. REGNELL1,2, G. A. HILDRESTRAND1, Y. SEJERSTED1, T. MEDIN1, O. MOLDESTAD1, V. ROLSETH1, S. Z. KROKEIDE1, R. SUGANTHAN1, L. LUNA1, *J. STORM-MATHISEN1, M. BJORAS1, L. H. BERGERSEN1,2;
1Univ. Oslo, Oslo, Norway; 2Univ. Copenhagen, Copenhagen, Denmark
Abstract: Accumulation of oxidative DNA damage has been proposed as a potential cause of age- related cognitive decline. The major pathway for removal of oxidative DNA base lesions is base excision repair, which is initiated by DNA glycosylases. In mice, Neil3 is the main DNA glycosylase for repair of hydantoin lesions in single stranded DNA of neural stem/progenitor cells, promoting neurogenesis. Adult neurogenesis is crucial for maintenance of hippocampus-dependent functions involved in behavior. Herein, behavioral studies revealed learning and memory deficits and reduced anxiety-like behavior in Neil3-/- mice. Neural stem/progenitor cells from aged Neil3-/- mice showed impaired proliferative capacity. Further, hippocampal neurons in Neil3-/- mice displayed synaptic irregularities. It appears that Neil3-dependent repair of oxidative DNA damage in neural stem/progenitor cells is required for maintenance of adult neurogenesis to counteract the age associated deterioration of cognitive performance.
Disclosures:  C.E. Regnell: None. G.A. Hildrestrand: None. Y. Sejersted: None. T. Medin: None. O. Moldestad: None. V. Rolseth: None. S.Z. Krokeide: None. R. Suganthan: None. L. Luna: None. J. Storm-Mathisen: None. M. Bjoras: None. L.H. Bergersen: None.
Keyword(s): PROLIFERATION
NEUROGENESIS
DNA REPAIR
Support: The Norwegian Health Association
The Norwegian Cancer Society
The Research Council of Norway
[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.

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