Phase/amplitude coupling supports network organization in human frontal cortex
Monday, Oct 15, 2012, 9:00 AM -10:00 AM
, D. BADRE
, A. S. KAYSER
, D. FEGEN
, E. F. CHANG
, N. E. CRONE
, J. PARVIZI
, R. T. KNIGHT
, M. D’ESPOSITO
Ernest Gallo Clin. and Res. Center, Dept. of Neurol.,
Departments of Neurolog. Surgery and Physiology, UCSF Ctr. for Integrative Neurosci., Univ. of California, San Francisco, San Francisco, CA;
Helen Wills Neurosci. Inst.,
Dept. of Psychology, Univ. of California, Berkeley, Berkeley, CA;
Dept. of Cognitive, Linguistic and Psychological Sci.,
Brown Inst. for Brain Sci., Brown Univ., Providence, RI;
Dept. of Neurology, Epilepsy Ctr., Johns Hopkins Med. Institutions, Baltimore, MD;
Stanford Human Intracranial Cognitive Electrophysiology Program (SHICEP),
Dept. of Neurol. and Neurolog. Sci., Stanford Univ., Stanford, CA
Humans and other primates have a capacity for hierarchical control, or the ability to simultaneously control immediate actions while also holding more abstract goals in mind. Recent neuroimaging and neuropsychological evidence in humans suggests that hierarchical control emerges from a frontal architecture wherein rostral regions of frontal cortex modulate neural processing in caudal frontal regions when abstract rules are used to govern behavior. The neural mechanisms underlying these processes are underspecified. Here we take advantage of the improved temporal and spatial resolution of human intracranial electrocorticography (ECoG) to investigate how anatomically separated frontal cortical regions interact to support hierarchical cognitive control. ECoG was recorded from subdural electrodes in four patients (top panel) being evaluated for surgery for intractable epilepsy (white circles outline task-responsive electrodes).
We demonstrate that responding according to progressively more abstract response rules is associated with: (1) increased high gamma activity over rostral prefrontal cortex (PFC) with increasing abstraction; (2) stronger theta coherence among task-related PFC regions (top 5% most theta-coherent electrode pairs), and; (3) stronger theta/gamma phase/amplitude coupling (PAC) within task-related regions (bottom panel, left). Task abstraction, from least to most, is in the order of R1/R2/D1/D2. Moreover, coherent regions have correlated theta/gamma PAC (bottom panel, center) and regions that participate in the task-related theta network have stronger theta/gamma PAC than those not participating in the task network (bottom panel, right). Our coherence and PAC results suggest that phase coherence dynamically coordinates local neuronal activity between frontal regions dependent on task demands. Taken together these findings provide a mechanism for coordination of neural processing in the human frontal cortex.
Phase amplitude coupling (theta gamma)
NINDS NS21135-22S1 & PO30813 (BV/RTK, RTK)
NINDS NS07839601 (JP)
NINDS R01 NS065046 (DB)
Department of Veterans Affairs, State of California (ASK)
NINDS K99/R00 NS065120 (EFC)
[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
2012 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
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