Silicon nanophotonics for the replacements of the damaged photorecptors in diseased retinas
Sunday, Oct 14, 2012, 9:45 AM -10:00 AM
*M. L. KHRAICHE
, Y. JING
, S. HA
, Y. LO
, W. FREEMAN
, E. CHICHILNISKY
, D. WANG
, G. CAUWENBERGHS
, G. A. SILVA
UCSD, San Diego, CA;
UCSD, La jolla, CA;
Jacobs retina center, La jolla, CA;
Salk Inst. for Biol. Studies, la jola, CA
Photoreceptor neurons are specialized cells capable of phototransduction at high sensitivity, responsivity and spatial resolution. Death of the photoreceptors due to retinal degenerative diseases renders the retina incapable of detecting light. Efforts aimed at stimulating the surviving retinal tissue show promise in restoring vision via targeted electrical stimulation. Our group is currently developing Silicon Nanowires that have the potential to match the form factor, spatial distribution, light detection and signal transduction characteristics of photoreceptors at a quantum efficacy nearing 50% in the visible spectrum, while providing a neural interface to the surviving retinal tissue on a scale comparable to those of proteins and lipids. Unlike current approaches aimed at replacing the function of the photoreceptors which rely on separate components for detecting light (via an external camera or micro-photodiodes) and stimulating neurons in the retina, our approach combines both light detection and stimulation in a single nanophotonic component, thereby reducing the footprint of the implant and its power consumption. We will show in vitro data on the spatial and temporal resolution of retinal ganglion cell activation due to stimulation by the nanowires in response to varying light intensities, introduce a flexible prototype of our nanoengineered implantable device, and summarize our progress and on-going work in vivo in animal models.
von Liebig Center for Entrepreneurism and Technology Advancement
[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
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