Effects of Bariatric Surgery on the Intestinal and Plasma Levels of Endogenous Cannabinoids
6/10/2012 12:00:00 PM
6/10/2012 2:00:00 PM
, ISABELLE MATIAS, SONIA LIPP, DARLEEN A. SANDOVAL, RANDY J.. SEELEY, DANIELA COTA,
Activation of the endocannabinoid system (ECS) is implicated in the pathogenesis of obesity as it promotes energy intake and storage. To determine whether weight loss with bariatric surgery decreases the ECS tone, we measured circulating and intestinal levels of 2 major endocannabinoids, anandamide (AEA) and 2 arachidonyl Glycerol (2-AG), in two bariatric surgery rodent models of dietary obesity induced with high-fat diet: Roux-en-Y-Gastric Bypass (RYGB) and Vertical Sleeve Gastrectomy (VSG). At 3 months from surgery, RYGB decreased body weight of obese male Long Evan rats as compared to sham-operated controls (575±40 and 767 ± 80 g in RYGB vs Sham, respectively, P<0.01 n=4). The levels of AEA were not decreased by RYGB either in plasma or throughout the intestine. Similarly, 2-AG was not changed in plasma and ileum. By contrast, RYGB significantly decreased 2-AG levels in duodenum, jejunum and liver. VSG in obese mice significantly reduced BW (37.9±1.6 and 43.9 ± 1.2 g in VSG vs Sham, respectively, P<0.05 n=6-7) and fat mass (12.2±1.3 and 18.3± VSG vs Sham, respectively, P<0.05). Unlike RYGB, VSG did not change the intestinal levels of AEA or 2-AG in any portion of the intestine. However, VSG resulted in a significant decrease in plasma AEA and 2-AG.
These results suggest that a potential mechanism for the weight reducing efficacy of RYGB and VSG is the reduction of endocannabinoids levels, with a tissutal response that depends on the type of bariatric surgery. The study of the ECS in bariatric surgery may unveil tissue-specific role of endocannabinoids that may be exploited for the treatment of obesity.
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