Sleeve Gastrectomy is Effective in Mice Lacking the Glucagon-Like Peptide-1 Receptor
6/10/2012 12:00:00 PM
6/10/2012 2:00:00 PM
, DIEGO PEREZ-TILVE, KAREN K. RYAN, DARLEEN A. SANDOVAL, ADAM P. CHAMBERS, DANIEL J. DRUCKER, RANDY J.. SEELEY,
Glucagon-Like Peptide-1 (GLP-1) is a peptide hormone that is released from the gut in response to nutrient ingestion, and has a range of metabolic effects including enhancing insulin secretion and decreasing food intake. Postprandial GLP-1 secretion is greatly enhanced following some bariatric procedures, including Vertical Sleeve Gastrectomy (VSG), and has been hypothesized to be at least partially responsible for the improvements in glucose homeostasis and other metabolic outcomes following these surgeries. We tested the hypothesis that GLP-1 action is necessary for the effects of VSG by performing VSG surgery in mice that lack the GLP-1 receptor (GLP-1rKO), and examining their metabolic and behavioral outcomes. We found that VSG-operated GLP-1rKO mice responded similarly to wild-type controls in terms of body weight and body fat loss, food intake reduction, meal patterns and food selection. VSG improved glucose tolerance in both wild-type and GLP-1rKO mice, overcoming the baseline glucose intolerance of the GLP-1rKO animals. We conclude that GLP-1 action is not essential for the metabolic improvements induced by VSG surgery.
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