Potential Role of the Intestinal Lipid Messenger OEA in the Effects of Sleeve Gastrectomy on Food Intake and Preference
6/10/2012 12:00:00 PM
6/10/2012 2:00:00 PM
, DANIELA COTA, ISABELLE MATIAS, RANDY J.. SEELEY, SILVANA OBICI,
Oleoylethanolamide (OEA) is a diet-derived intestinal lipid messenger that promotes satiety by acting on peripheral sensors located in the gut. We have found that the weight-reducing bariatric procedure Vertical Sleeve Gastrectomy (VSG) increases OEA levels in the duodenum (0.48+- 0.02 versus 0.75+- 0.09, sham and VSG mice respectively N=6-7 p<0.05) in high-fat diet-induced obese mice, without significant changes in ileum, jejunum or plasma levels. We have previously published that VSG results in a marked weight-independent reduction in the secretion of intestinal triglycerides. Thus, the increased levels of duodenal OEA occur despite a lower dietary supply of fatty acid precursors.
OEA has been shown to increase meal frequency, and has been suggested to play a role in fat intake. We tested the effect of VSG on food intake, food preference and meal pattern. VSG mice have significantly reduced body weight and fat mass, but display daily calorie intake similar to sham operated mice following a transient hypophagia in the first 3 post-operative weeks. Despite normal daily calorie intake, meal frequency was increased in VSG compared to Sham mice. Using a macronutrient selection paradigm to examine food choice, we found that VSG-operated mice decrease their fat intake and increase their carbohydrate intake compared to sham-operated controls.
The changes in food intake, meal pattern and food preferences in VSG mice reproduce several of the anorectic effects of OEA. Taken together these results point to OEA as a potential intestinal mediator of the VSG-induced effects on food intake and food preference.
When adding presentations to your Itinerary, please click "Add Checked Selections to My Itinerary" on
page of your search results.
Authors listed in
are the presenting authors for those abstracts that have presentations.
American Diabetes Association
1701 North Beauregard Street
Alexandria, VA 22311
The Online Abstract Submission and Invitation System
© 1996 - 2015 Coe-Truman Technologies, Inc. All rights reserved.