Presentation Abstract

Session: Poster Session
Abstract Number: 1980-P
Title: Gastric Bypass Surgery Modifies Ethanol Consumption
Presentation Start: 6/10/2012 12:00:00 PM
Presentation End: 6/10/2012 2:00:00 PM
Authors: JON F. DAVIS, JENNIFER D.. SCHURDAK, IRWIN J. MAGRISSO, JORAM MUL, BERNADETTE E. GRAYSON, PAUL T. PFLUGER, MATTHIAS H. TSCHOP, RANDY J.. SEELEY, STEPHEN C. BENOIT, Cincinnati, OH.
Abstract: Roux en Y gastric bypass (RYGB) surgery is an effective weight loss strategy employed to treat obesity and associated complications. Importantly, the RYGB procedure has been reported to modify alcohol intake. Prior studies report increased alcohol intake in RYGB patients following surgery; a more recent study concluded that despite no observable change in intake following surgery, bariatric patients have a higher lifetime prevalence of alcohol misuse. Thus, it is unclear if RYGB surgery is capable of altering alcohol intake. The present work examined the hypothesis that RYGB surgery mediates alcohol intake and reward in individuals that frequently consume alcohol. To do this, alcohol intake was examined in human bariatric patients (n=6,165) who self-reported alcohol intake prior to receiving the RYGB procedure. In addition we utilized a rodent model of RYGB and examined ethanol consumption and ethanol reward in male alcohol preferring (P) rats which are selectively bred to consume large volumes of ethanol. Patients that self-reported occasional-frequent alcohol use reported decreased usage following RYGB surgery. Moreover, the RYGB procedure decreased ethanol intake and the reinforcing properties of ethanol in P rats. Notably, the attenuating effect of RYGB surgery on ethanol consumption was associated with ethanol-induced excursions in the gut hormone glucagon like peptide-1 (GLP-1). Pharmacological manipulation of GLP-1 signaling modulated ethanol consumption in P rats. In addition, pharmacological replacement of the gut hormone ghrelin restored drinking behavior in P rats following RYGB. These data indicate that baseline alcohol consumption may explain the variety of outcomes reported in patients that undergo RYGB. Moreover, this work details the neuroendocrine signaling mechanisms which modify consummatory behaviors following RYGB surgery





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