Molecular Mechanism of Synchronous Neurotransmitter Release
Sunday, Oct 14, 2012, 5:15 PM - 6:25 PM
Dept. of Chem., Yale Univ. Sch. of Med., New Haven, CT
Synchronous transmitter release enables neural circuits to keep pace, and results when docked synaptic vesicles are rapidly triggered to fuse with the pre-synaptic plasma membrane by calcium ions entering the nerve terminal. Membrane fusion in the nerve terminal and elsewhere is mediated by SNARE proteins which assemble between the vesicle and plasma membrane. Biochemical studies have recently established that only two additional synapse-specific proteins - synaptotagmin and complexin - are needed to synchronize release by SNAREs and to add calcium dependence. Complexin cross-links assembling SNAREs into a highly co-operative array, freezing the frame of vesicle fusion to synchronize the readily-releasable pool. Upon binding calcium, Synaptotagmin releases the frozen SNAREs enabling them to rapidly complete assembly and release transmitter at the right time and place.
NIH Grant - 2 R01 GM071458-08
[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
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