Presentation Abstract

Program#/Poster#: 924.03/FFF17
Presentation Title: Effect of the Toll-like receptor 4 antagonist (+)- naltrexone on incubation of heroin craving
Location: Hall F-J
Presentation time: Wednesday, Oct 17, 2012, 3:00 PM - 4:00 PM
Authors: S. KAMBHAMPATI1, H. EICHENBAUM1, C. L. PICKENS1, J. M. BOSSERT1, K. RICE2, L. R. WATKINS3, Y. SHAHAM1, *F. R. THEBERGE1;
1NIH/NIDA BRC, Baltimore, MD; 2Natl. Inst. on Alcohol Abuse and Alcoholism, Natl. Inst. of Hlth., Rockeville, MD; 3Dept. Psychology & Neurosci., Univ. Colorado At Boulder, Boulder, CO
Abstract: Recent evidence implicates the glial toll-like receptor 4 (TLR4) in morphine analgesia, tolerance, and reward, as assessed in the conditioned place preference procedure. Here we used the selective TLR4 antagonist (+)-naltrexone (a µ-opioid receptor inactive isomer) to determine the role of this receptor in the time-dependent increases in cue-induced heroin seeking during forced abstinence (incubation of heroin craving). We trained rats for 9 h/day to self-administer heroin (0.1 mg/kg/infusion) for 9 days; lever presses were paired with a 5-sec tone-light cue. We then assessed cue-induced heroin seeking in 30-min extinction sessions on abstinence day 1; immediately after testing, we implanted the rats with Alzet minipumps delivering (+)-naltrexone (0, 15.0, or 30.0 mg/kg/day, s.c) for 14 days. We then tested the rats for incubated cue-induced heroin seeking in 3-h extinction tests on abstinence day 13. We found that both doses of (+)-naltrexone decreased cue-induced heroin seeking on abstinence day 13. Results suggest a critical role of the glial TLR4 in the development of incubation of heroin craving. We currently study the effect of acute injections of (+)-naltrexone on incubation of heroin craving.
Disclosures:  S. Kambhampati: None. H. Eichenbaum: None. C.L. Pickens: None. J.M. Bossert: None. K. Rice: None. L.R. Watkins: None. Y. Shaham: None. F.R. Theberge: None.
Keyword(s): RELAPSE
HEROIN
TOLL-LIKE RECEPTOR 4
Support: NIDA IRP
[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.

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