Effect of the Toll-like receptor 4 antagonist (+)- naltrexone on incubation of heroin craving
Wednesday, Oct 17, 2012, 3:00 PM - 4:00 PM
, H. EICHENBAUM
, C. L. PICKENS
, J. M. BOSSERT
, K. RICE
, L. R. WATKINS
, Y. SHAHAM
, *F. R. THEBERGE
NIH/NIDA BRC, Baltimore, MD;
Natl. Inst. on Alcohol Abuse and Alcoholism, Natl. Inst. of Hlth., Rockeville, MD;
Dept. Psychology & Neurosci., Univ. Colorado At Boulder, Boulder, CO
Recent evidence implicates the glial toll-like receptor 4 (TLR4) in morphine analgesia, tolerance, and reward, as assessed in the conditioned place preference procedure. Here we used the selective TLR4 antagonist (+)-naltrexone (a µ-opioid receptor inactive isomer) to determine the role of this receptor in the time-dependent increases in cue-induced heroin seeking during forced abstinence (incubation of heroin craving). We trained rats for 9 h/day to self-administer heroin (0.1 mg/kg/infusion) for 9 days; lever presses were paired with a 5-sec tone-light cue. We then assessed cue-induced heroin seeking in 30-min extinction sessions on abstinence day 1; immediately after testing, we implanted the rats with Alzet minipumps delivering (+)-naltrexone (0, 15.0, or 30.0 mg/kg/day, s.c) for 14 days. We then tested the rats for incubated cue-induced heroin seeking in 3-h extinction tests on abstinence day 13. We found that both doses of (+)-naltrexone decreased cue-induced heroin seeking on abstinence day 13. Results suggest a critical role of the glial TLR4 in the development of incubation of heroin craving. We currently study the effect of acute injections of (+)-naltrexone on incubation of heroin craving.
TOLL-LIKE RECEPTOR 4
[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
2012 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
Please remember to create a new itinerary account for this year before adding items to your itinerary.
When adding items to your Itinerary, please click "Add Checked Selections to My Itinerary" on
page of your search results.
About the Meeting
Fellowships, Awards, and Prizes
Frequently Asked Questions
Download Abstracts and
Daily Books (updated 10/13/2012) to Your E-Reader Devices
OASIS Technical Support.
Monday - Friday, 9 am - 5 pm CT
The Online Abstract Submission and Invitation System
© 1996 - 2014 Coe-Truman Technologies, Inc. All rights reserved.