Differentially recruited brain areas for familiar and unfamiliar segments of a progressively presented musical sequence.
Monday, Oct 15, 2012, 11:00 AM -12:00 PM
*B. M. GREEN
, J. SALMI
, I. JÄÄSKELÄINEN
, M. SAMS
, J. RAUSCHECKER
Dept. of Neurosci., Georgetown Univ. Med. Ctr., Washington, DC;
Dept. of Biomed. Engin. and Computat. Sci., Aalto University, Sch. of Sci., Espoo, Finland
Perceiving multiple sounds as a sequence requires the learning and storage of an ordered progression, but the exact mechanisms for this are largely unknown. A tight coupling between auditory and motor systems in speech and music perception has been widely documented (Zatorre et al., 2007), and the dorsal auditory stream has been implicated in sensorimotor integration and concatenation of sequential events (Rauschecker, 2011). Motor areas such as the basal ganglia and cerebellum have been linked to learning new sound sequences but not to storage of well-known songs (Leaver et al., 2009). Auditory sequence processing seems to depend on generalized sequencing abilities borrowed from the motor system, but the functional and anatomical transition of similar stimuli from sequence-encoding to sequence-storing has yet to be shown in humans.
This study aimed to investigate the processing of familiar and unfamiliar segments of the same musical sequence. Two subjects listened to musical sequences in the scanner while performing either an auditory or visual attention task. The musical stimulus consisted of a 30-second melody (180 beats per minute) progressively presented, beginning with only the first second of music and adding an additional second on each repeat, until the sequence was heard in its entirety. Subjects heard early sequence segments 20-30 times (relatively familiar), while late segments were heard 1-10 times (relatively unfamiliar).
FMRI data processing was carried out using FEAT analysis in FSL. Z statistic (Gaussianized T) images were thresholded using clusters determined by Z>2.7 and a (corrected) cluster significance threshold of P=0.05. Unfamiliar sequence segments were associated with right-lateralized activity in Heschl's Gyrus, Planum Temporale, Supramarginal Gyrus, Posterior Superior Temporal Gyrus, and Dorsal Prefrontal Cortex (PFC), as well as left-lateralized activity in Medial PFC and Inferior Temporal Gyrus. Familiar sequence segments were associated with right-lateralized activity in Anterior PFC, Superior Parietal Lobule, and Angular Gyrus, as well as left lateralized activity in Primary and Supplementary Motor Cortex, and Inferior Frontal Gyrus. Additionally, familiar sequences showed bilateral activation in Cingulate and Paracingulate Gyri as well as visual areas such as Precuneus, Intracalcarine Sulcus, Lingual Gyrus, and Fusiform Gyrus. These preliminary results suggest a differential recruitment of brain areas for familiar
. unfamiliar musical sequences.
Academy of Finland (FiDiPro No. 118370)
Academy of Finland (CoE No. 129670)
[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
2012 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
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