Presentation Abstract

Session: 06-Nutrition
Tuesday, Mar 02, 2010, 5:00 PM - 7:00 PM
Presentation: P33 - Coffee Consumption in Young Adulthood and Subclinical Atherosclerosis Later in Life: The CARDIA Study
Location: Grand Ballroom A
Pres. Time: Tuesday, Mar 02, 2010, 5:00 PM - 7:00 PM
Category: +NPAM - Nutrition
Keywords: Diet; Carotid arteries; Epidemiology
Author(s): Jared P Reis, Catherine M Loria, Natl Heart, Lung, and Blood Inst, Bethesda, MD; Lyn M Steffen, Xia Zhou, Univ of Minnesota, Minneapolis, MN; Linda van Horn, Northwestern Univ, Chicago, IL; David S Siscovick, Univ of Washington, Seattle, WA; David R Jacobs Jr, Univ of Minnesota, Minneapolis, MN; J Jeffrey Carr, Wake Forest Univ Sch of Med, Winston-Salem, NC
Abstract: Background: Although the relation of coffee consumption with established metabolic risk factors for coronary heart disease (CHD) and incident CHD events has been a topic of frequent interest, few studies have determined whether coffee may be associated with atherosclerosis.
Methods: The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a cohort of 5,115 white and black men and women who were 18-30 years when they completed a baseline clinic examination in 1985-1986. Subsequent examinations were conducted 2, 5, 7, 10, 15, and 20 years later. Coffee consumption (over the past 30 days) was determined with an interviewer-administered diet history questionnaire at baseline and year 7. The average from both examinations was used in analyses. Subclinical coronary artery calcified (CAC) plaque was measured with non-contrast cardiac computed tomography at years 15 and 20. Maximal carotid intima-media wall thickness (cIMT) was measured at two sites with B-mode ultrasound at year 20. The top quintile was used to define high cIMT at both locations.
Results: Approximately 22.8% had a CAC present defined as a score >0 at year 15 (prevalence=11.2%) or year 20 (prevalence=18.5%). Among those free of CAC at year 15 (n=2,173), 10.4% developed incident CAC by year 20. Overall, 33.6% reported no coffee consumption, while 22.8%, 18.6%, 16.2%, and 8.8% reported less than one, 1-2, 3-4, and > 4 cups/day, respectively. In multivariable analyses adjusted for age, sex, race, education, clinic location, BMI, smoking, alcohol, energy intake, fruit and vegetable consumption, and whole and refined grain intake, coffee consumption did not increase or decrease odds for prevalent or incident CAC or high cIMT at either location (Table 1). Use of information on coffee consumption at year 20 and stratification by sex, race, or smoking status yielded similar results.
Conclusion: These data suggest coffee consumption in young adulthood does not influence these measures of subclinical coronary and carotid atherosclerosis later in life.
Table 1. Multivariable-adjusted association of average coffee consumption at years 0 and 7 with measures of subclinical atherosclerosis at years 15 or 20: the CARDIA Study.
Coffee consumption (cups/day)
0< 11-23-4> 4p for linear trend
Prevalent CAC at years 15 or 20, n=3,624
Cases/noncases192/962189/953115/465104/40173/170
OR (95% CI)*1.00 (referent)0.94 (0.74, 1.19)0.96 (0.72, 1.28)0.87 (0.64, 1.19)1.17 (0.81, 1.70)> 0.2
Incident CAC at year 20, n=2,173
Cases/noncases72/59468/63541/32125/27920/118
OR (95% CI)*1.00 (referent)0.94 (0.64, 1.36)0.94 (0.60, 1.46)0.59 (0.35, 1.01)1.04 (0.57, 1.90)> 0.2
High internal carotid IMT, n=3,174
Cases/noncases185/806192/818105/405103/35249/159
OR (95% CI)*1.00 (referent)1.07 (0.84, 1.35)1.17 (0.87, 1.57)1.30 (0.95, 1.76)1.00 (0.67, 1.50)> 0.2
High common carotid IMT, n=3,207
Cases/noncases214/788205/82097/41889/36837/171
OR (95% CI)*1.00 (referent)1.00 (0.78, 1.27)0.94 (0.69, 1.29)1.11 (0.80, 1.54)0.72 (0.45, 1.13)> 0.2
OR, odds ratio; CI, confidence interval.
*Adjustment variables included age, sex, race, education, clinic location, BMI, smoking, alcohol, energy intake, fruit and vegetable consumption, and whole and refined grain intake.
Disclosures:  J.P. Reis: None. C.M. Loria: None. L.M. Steffen: None. X. Zhou: None. L. van Horn: None. D.S. Siscovick: None. D.R. Jacobs: None. J.J. Carr: None.