Presentation Abstract

Program#/Poster#: 337.11/E18
Title: Loaded wheel running enhance BDNF function in the rat hippocampus
Location: Halls B-H
Presentation Time: Monday, Nov 15, 2010, 10:00 AM -11:00 AM
1Exercise Biochem., Univ. of Tsukuba, Tsukuba-Si, Ibaraki-Ken, Japan; 2Inst. of Basic Med. Sci., Univ. of Tsukuba, Tsukuba, Japan
Abstract: It is well known that physical exercise produces numerous changes not only in the body, but also in brain and mental functions. In particular, physical exercise induces synaptic plasticity in the hippocampus, a site critical for learning, memory, and cognitive functions. These hippocampal functions are related to brain-derived neurotrophic factor (BDNF), a growth factor of the neurotrophin family that supports the growth, development, maintenance, and survival of the neuronal system. In addition, accumulating evidence suggests that BDNF may play important roles in memory, learning, mood disorders, and energy metabolism. Studies have shown that voluntary wheel running increases the expression of brain BDNF and its receptor (tyrosine protein kinase receptor; TrkB), which mediates the improvement of memory and learning in rodents. In general, voluntary wheel running (relatively low-intensity and long-duration type) upregulates BDNFmRNA expression in the hippocampus. However, in such studies, the total distance run is usually recorded, but the running rates and loads are unknown. In contrast, loaded wheel running is a condition where there is a load during the voluntary running activity. It is possible that when a strength or power type activity is used (relatively high intensity and short duration), fewer apparent metabolic adaptations result, but muscle fiber hypertrophy is elicited. The purpose of this study was to determine the effects of voluntary wheel running with an additional load on BDNF induction and its molecular signaling in the rat hippocampus.
To address this, ten-week old male Wistar rats (7 rats/group) were assigned randomly to 1) a sedentary control group (Control), 2) a voluntary exercise with no load group (No-Load), or 3) a voluntary exercise with additional load group (Load) for 4 weeks. The load for the Load group was progressively increased to reach ~30% of body weight during the last week of training. As a result, we found mean distance levels reduced by about half (53%); however, mean work levels significantly increased in the Load group. The relative plantaris weights were greater in the Load group compared with the Control groups. Further, loaded wheel running up-regulated gene expressions in BDNF and its signaling molecules. The induction levels of BNDFmRNA had a high correlation with work levels in the Load group (r = 0.93), but not in the No-Load group. Here we found for the first time that loaded wheel voluntary running, which causes a muscular adaptation, results in enhanced gene expression of both BDNF and its signaling molecules, suggesting a possible role of high-intensity short-term exercise on hippocampal BDNF actions.
Disclosures:  L. Minchul: None. H. Nogami: None. K. Inoue: None. M. Okamoto: None. T. Matsui: None. H. Soya: None.
Keyword(s): LWR(loaded wheel running)
[Authors]. [Abstract Title]. Program No. XXX.XX. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online.

2010 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.

Note: When adding items to your Itinerary, please click "Add Checked Selections to My Itinerary" on EACH page of your search results.

About the Meeting





Attendee Resources


Fellowships, Awards, and Prizes

Frequently Asked Questions

Final Program