Presentation Abstract

Session: 158-Pediatrics
Thursday, Sep 12, 2013, 11:00 AM - 1:00 PM
Presentation Title: G-1249 - Vitamin D (VD) Supplementation Reduces the Risk of Acute Otitis Media (AOM) in Otitis-prone Children
Location: Exhibit Hall A
Presentation Number: G-1249
Pres. Time: Thursday, Sep 12, 2013, 11:00 AM - 1:00 PM
Category: G2
Keywords: Acute otitis media; Otorrhea; Vitamin D
Author(s): S. Esposito1, P. Marchisio1, D. Consonni2, E. Baggi1, A. Zampiero1, S. Bianchini1, L. Terranova1, S. Tirelli3, N. Principi1;
1Pediatric Clin. 1, Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliClin., Univ. degli Studi di Milano, Milan, ITALY, 2Epidemiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliClin., Milan, ITALY, 3Lab. Med. Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliClin., Milan, ITALY.
Financial Disclosures:  S. Esposito, None..
P. Marchisio, None..
D. Consonni, None..
E. Baggi, None..
A. Zampiero, None..
S. Bianchini, None..
L. Terranova, None..
S. Tirelli, None..
N. Principi, None.
Abstract: Background: AOM is common in the first years of life. In many children it tends to frequently recur. Methods currently used to prevent new episodes of AOM in otitis-prone children are frequently ineffective. VD may modulate the incidence and severity of bacterial and viral infections. This study has evaluated whether a deficit in VD is associated with an increased risk of recurrent AOM (rAOM), and whether VD supplementation could reduce the number of AOM cases in otitis-prone children. Methods: A total of 116 children with rAOM (≥3 episodes in preceding 6 months, or ≥4 in preceding 12 months) were prospectively and blindly randomized to receive oral VD 1,000 IU/day or placebo for 4 months. Episodes of AOM were monitored for 6 months. Results: Fifty-eight children received placebo and 58 matched controls VD. The number of children with ≥1 AOM episode during the study period was significantly lower in the VD group (26 vs 38; p=0.03). There was a marked difference in the number of children who developed uncomplicated AOM (p<0.001), but no difference in the number of children with ≥1 episode of spontaneous otorrhea. The likelihood of AOM was significantly reduced in the patients whose serum VD levels were ≥30 ng/mL. Conclusions: VD hypovitaminosis is common in children with rAOM and associated with an increase in the occurrence of AOM when serum 25(OH)D levels are <30 ng/mL. The administration of VD in a dosage of 1,000 IU/day restores serum values of ≥30 ng/mL in most cases and is associated with a significant reduction in the risk of uncomplicated AOM.




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