Presentation Abstract

Session Title: Bioengineering
Location: Hall C
Presentation Number: 3539-Pos
Board Number: B694
Presentation Time: 2/6/2013 10:30:00 AM
Abstract Title: IMPACT OF INITIAL VASCULAR PERMEABILITY AND RECOVERY SPEED OF DISRUPTED BLOOD-BRAIN BARRIER ON NANODRUG DELIVERY INTO THE BRAIN TISSUE
Author Block: Kuo-Wei Lu1, Hsin-Yu Wu1, Chih-Kang Huang2, Tzyy-Leng Horng3, Cheng-Ying Chou2, Win-Li Lin1,4.
1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, 2Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei, Taiwan, 3Department of Applied Mathematics, Feng Chia University, Taichung, Taiwan, 4Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan.
Abstract Body:
Delivery of drugs across Blood-brain barrier (BBB) can be enhanced by physical stimulation (e.g. ultrasound). When BBB is opened by ultrasound sonication in the presence of microbubbles, its vascular permeability will decay due to BBB repairing. The transport and accumulation of nanodrugs in brain tissue is affected by both physicochemical properties of drugs and closure dynamics of BBB. In this study, we developed a mathematical model and employed animal experiments to investigate the impact of recovery of disrupted BBB on nanodrug delivery into brain tissue. We chose Evans blue (EB)-albumin complexes as a model nanodrug and studied the effects of initial permeability, decaying speed of permeability and half-life of EB-albumin complexes on their spatial-temporal concentration response and accumulation in brain tissue. The transport
parameters used in this model were obtained from previously published studies and the fitting of our experimental data with Particle Swarm Optimization (PSO). The simulation results showed that there exists optimal initial permeability and decaying speed of permeability to achieve a maximum AUC (area under the concentration-time curve) of EB-albumin in the brain tissue. The results indicate that we can enhance the accumulation of nanodrugs safely in brain tissue by controlling the recovery dynamics of BBB opening.
Commercial Relationship:  K. Lu: None. H. Wu: None. C. Huang: None. T. Horng: None. C. Chou: None. W. Lin: None.


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