Collective dynamics of high density EEG reveals a single dominant mode of activity during general anesthesia-induced unconsciousness
Monday, Nov 15, 2010, 11:00 AM -12:00 PM
, E. T. PIERCE
, A. F. SALAZAR GOMEZ
, J. WALSH
, P. G. HARRELL
, C. L. TAVARES-STOECKEL
, K. HABEEB
, P. PURDON
, E. N. BROWN
Dept. of Anesthesia and Critical Care, Massachusetts Gen. Hosp., Boston, MA;
Harvard Med. Sch., Boston, MA;
Dept. of Brain and Cognitive Sci., MIT, Cambridge, MA
Characterizing the collective activity of different brain areas from electroencephalogram (EEG) measurements is essential for understanding states such as general anesthesia, epilepsy, coma and sleep. Although some EEG signatures have been identified, signatures for the collective behavior of EEG for these states have not been established. We performed global coherence analysis to quantify the collective dynamics of high density EEG recordings in subjects that go through general anesthesia-induced unconsciousness while performing an auditory discrimination task. This analysis provides a time and frequency dependent characterization of the data that reflects the most correlated eigenmode and the spatial contributions to this mode. We provide evidence of coherent activity on the frontal cortex at high drug doses. This activity appears within sustained periods of low alpha power and high delta power on the occipital cortex (alpha-delta ratio, ADR<1) during which subjects show no response to the behavioral task. In contrast, we observed consistently high ADR (ADR>1) on the occipital cortex during the eyes closed, awake state. Our approach uses the Laplacian montage which allows us to obtain results that are independent of the choice of reference. It has been suggested that during general anesthesia-induced unconsciousness, interruption of communication in different areas may result in the brain’s inability to integrate information. Here, we suggest that the coherent activity in the frontal areas reflects break down of normal communication between brain regions.
A.F. Salazar Gomez:
NIH DP1 OD003646 (ENB)
GCRC 1 UL1 RR025758-01
[Authors]. [Abstract Title]. Program No. XXX.XX. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online.
2010 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
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