Presentation Abstract

Session: P04-Novel Risk Factors
Friday, Mar 25, 2011, 5:15 PM - 7:15 PM
Presentation: P322 - Gender Modifies the Association between Sleep Habits and Cardiovascular Disease Risk Factors
Location: P322
Pres. Time: Friday, Mar 25, 2011, 5:15 PM - 7:15 PM
Category: +EPI - Sleep
Keywords: Cardiovascular disease; Risk factors; Prevention
Author(s): Matthew Mosca, Franklin and Marshall Coll, Lancaster, PA; Brooke Aggarwal, Columbia Univ Medical Ctr, New York, NY
Abstract: Background: Lack of sleep has been associated with an increased risk for cardiovascular disease (CVD) and all-cause mortality, but the mechanisms are not fully understood. Prior research has often been conducted in select populations and has not consistently adjusted for confounders, especially psychosocial factors. The purpose of this study was to assess the association between sleep habits and established risk factors for CVD, and to evaluate potential interactions by race and gender. Methods: Participants were part of an NHLBI-supported evaluation of a CVD screening and educational outreach program. Free-living men > 40 years and women > 50 years (n = 371, mean age 60 years, 57% female, 60% racial/ethnic minorities) were systematically assessed for CVD risk (including traditional, lifestyle, and psychosocial risk factors) and completed a standardized questionnaire regarding sleep habits (including sleep duration and snoring). Number of hours of sleep per night was classified as < 6 vs. > 6 hours. Snoring was categorized as yes vs. no. Lipids were analyzed by validated fingerstick technology. Stress at work and home was assessed using a validated screening tool from the INTERHEART study. Associations between participants’ sleep habits and CVD risk factors/demographic factors were assessed using multivariable logistic regression. Results: The proportion of participants who reported sleeping < 6 hours/night on average was 28% (105/371) and 52% of participants (193/371) reported snoring. Sleeping < 6 hours/night was significantly associated with female sex, being single, increased stress at home, increased financial stress, and LDL-C. Gender modified the association between sleep duration and LDL-C (p = 0.04); sleeping <6 hours/night was significantly associated with reduced LDL-C among women, and increased LDL-C among men. Snoring was significantly associated with low HDL-C (<40mg/dL men/<50mg/dL women), being married, increased stress at work and home, <30 min exercise/day, < 5 servings of fruits and vegetables/day, and being overweight/obese (BMI>25 kg/m²). The association between snoring and low HDL-C remained significant in logistic regression models adjusted for demographic confounders (OR = 1.83, 95% CI = 1.06 - 3.19) but not after adjustment for BMI >25 kg/m². Conclusions: Sleeping < 6 hours/night was associated with several traditional and psychosocial CVD risk factors, and snoring was associated with low HDL-C, likely mediated through overweight/obesity. Research evaluating the relation between sleep habits and clinical CVD should consider interaction by gender as well as potential lifestyle and psychosocial factors. These data may have significance for clinicians to identify individuals who may be at increased CVD risk based on sleep habits.
Disclosures:  M. Mosca: None. B. Aggarwal: None.