Presentation Abstract

Program#/Poster#: 635.1
Title: The impact of 8 wks of aerobic or resistance exercise on spatial memory and hippocampal BDNF of rodents
Location: Room 7B
Presentation Time: Tuesday, Nov 16, 2010, 1:00 PM - 1:15 PM
Authors: *R. C. CASSILHAS1, J. FERNANDES1, M. G. M. OLIVEIRA1, L. B. FERREIRA2, S. TUFIK1, M. T. DE MELLO1;
1Psychobiology, 2Phisiology, Univ. Federal De São Paulo, São Paulo, Brazil
Abstract: Rodent studies demonstrated that exercise can improve learning and memory in various hippocampal-dependent tasks including Morris water maze (MWM), whereas these studies used aerobic exercise, running wheel or swimming to show these improvements. Although the resistance training can impact brain function in humans, we do not know if a rodent model of resistance exercise can affect learning and memory in the same way aerobic exercise does. In this sense, the goal of this study was to investigate the impact of 8 wks of aerobic or resistance exercise on spatial learning and memory and hippocampal BDNF of rodents. Wistar adult rats were distributed in four groups (n=10): Control Group (CTRL), Sham Group (SHA), Aerobic Group (AERO), and Resistance Group (RES). The AERO and RES groups were submitted to 8 wks of five weekly sessions of exercise in treadmill or vertical ladder apparatus (with a load secured to the tail), respectively. CTRL group was kept in the cage during all experiments with five minutes a day of manipulation. SHA group was kept in the same room and the apparatus (treadmill and vertical ladder) during the training of AERO and RES groups. After the last training session, all groups were submitted to MWM. In the training phase, rats were exposed 4 times to the MWM over 2 days. Each rat was given 60s to randomly explore water maze. After the training phase, in the spatial acquisition test (spatial learning) rats were submitted to 3 blocks of 4 swims separated by a 30 min interval, each rat was given 60s to reach the platform. The probe trial test which was conducted after a 30min break of spatial acquisition test, involved removing the platform and the rats undergoing a single trial of 60s. After 8 wks intervention, all four groups showed a reduction on escape latency, across blocks of trials, indicating spatial acquisition. Moreover, when compared to CTRL and SHAN groups, AERO and RES groups decreased the latency time in the three blocks of trials. On the probe trial, AERO and RES groups spent more time in the platform zone than the CTRL and SHA groups. For the hippocampal BDNF, both AERO and RES groups showed higher levels in comparison to CTRL and SHAN groups. AERO and RES groups showed better and faster spatial learning and memory also higher BDNF concentration when compared to CTRL and SHA groups. Furthermore, it was not founded any statistically difference between AERO and RES groups in the variables measured. In this sense, these results had been showed which aerobic and resistance exercise can improve spatial memory and can activate the BDNF pathway similarly.
Disclosures:  R.C. Cassilhas: None. J. Fernandes: None. M.G.M. Oliveira: None. L.B. Ferreira: None. S. Tufik: None. M.T. de Mello: None.
Keyword(s): memory
exercise
BDNF
Support: Psychopharmacology Research Support Association (AFIP)
Research Innovation and Dissemination Centers – SLEEP (CEPID-Sleep)
The State of São Paulo Research (FAPESP)
the Psychobiology and Exercise Research Center (CEPE)
National Council for Scientific and Technological Development (CNPq)
[Authors]. [Abstract Title]. Program No. XXX.XX. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online.

2010 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.




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