Presentation Abstract

Session: APS.204.03-Cardiovascular Risk
Presentation: 18709 - Older Former Smokers with <32 Pack-Years of Prior Smoking and <15 Years of Abstinence Have Lower Risk of Incident Heart Failure and Cardiovascular Mortality But Not of All-Cause Mortality: Findings From a Prospective Population Study
Pres Time: Wednesday, Nov 20, 2013, 9:30 AM -11:00 AM
Location: Hall F, Core 2, Poster Board: 2006
Pres. Time: Wednesday, Nov 20, 2013, 9:30 AM -11:00 AM
Specialty: +205. Prevention, Education, and Disease Management
Keywords: Smoking; Heart failure; Elderly; Health education
Authors: Amiya A Ahmed, Charity J Morgan, Univ of Alabama at Birmingham, Birmingham, AL; Gregg C Fonarow, Univ of California, Los Angeles, Los Angeles, CA; Sumanth Prabhu, Vera Bittner, Kanan Patel, Univ of Alabama at Birmingham, Birmingham, AL; Prakash Deedwania, Univ of California, San Francisco, San Francisco, CA; Gerasimos Filippatos, Univ of Athens, Athens,, Greece; Stefan D. Anker, Charité - Univsmedizin Berlin, Berlin, Germany; Richard M. Allman, Univ of Alabama at Birmingham, Birmingham, AL; Wilbert Aronow, New York Medical Coll, Valhalla, NY; Ali Ahmed, Univ of Alabama at Birmingham, Birmingham, AL
Abstract: Background: According to the US Surgeon General, the cardiovascular (CV) risk of former-smokers may become similar to that of never-smokers after 15 years of abstinence. We have previously demonstrated that former heavy smokers (≥32 pack-years) may still be at increased risk of incident heart failure (HF) despite >15 years of abstinence (Circulation 2010; 122: A17788 and Circulation 2011; 124: A18263). In the current study, we examined the risk of incident HF and mortality in former light and heavy smokers who quit ≤15 years ago.

Methods: Of the 3410 community-dwelling adults, age ≥65 yrs, free of baseline HF, in the Cardiovascular Health Study, 2557 were never-smokers and 853 were former-smokers who quit ≤15 (median, 8) years ago. Heavy smoking was defined as ≥32 PY of smoking. Cox regression models were adjusted for age, sex and race only as other baseline confounders were likely affected by prior smoking and acted as mediators.

Results: Unadjusted and age-sex-race adjusted associations of former smoking with outcomes during 13 years of follow-up are displayed in the Table.

Conclusions: We found no evidence of higher risk for incident HF and CV mortality among former light smokers who quit 15 or fewer (median, 8) years ago when compared with never smokers, although the risk for all-cause and non-CV mortality was higher. Former heavy smokers had significantly higher risk for all outcomes.

Disclosures:  A.A. Ahmed: None. C.J. Morgan: None. G.C. Fonarow: Consultant/Advisory Board; Modest; Medtronic, Johnson & Johnson. Employment; Significant; Eliot Corday Chair of Cardiovascular Medicine and Science. Research Grant; Significant; NIH, Gambro, Medtronic. Other Research Support; Significant; Ahmanson Foundation. S. Prabhu: None. V. Bittner: None. K. Patel: None. P. Deedwania: None. G. Filippatos: None. S.D. Anker: None. R.M. Allman: None. W. Aronow: None. A. Ahmed: None.

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