Presentation Abstract

Title: P17.5 - Y chromosome haplogroup analysis to estimate genetic origin of Balts
Keywords: Y haplogroups; ethnogenetics; Balts
Authors: A. Puzuka1, L. Pliss2, L. Piekuse1, S. Limborska3, A. Krumina2;
1Riga Stradins University, Laboratory of Molecular Genetics, Riga, Latvia, 2Latvian Biomedical Research and Study Centre, Riga, Latvia, 3Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russian Federation.
Abstract: Background. To obtain a more accurate portrait of ancestry of Balts Y chromosome haplogroupe (Y-hg) structure was determined in Russian individuals that inhabit historical regions of Baltic tribes and compared with incidence of Y-hg in Latvian population.
Material and methods. A study comprised 192 men - representatives of four Northern-Western Russian regions (Mezen, Ustyuzhna, Sychevka, Starista) and 153 men representing Latvian subpopulations. To establish Y haplogroups DNA samples were hierarchically genotyped (using appropriate PCR followed by RFLP or sequencing) by 13 Y chromosomal binary markers (M9, SRY-1532, M17, Tat, M178, M170, P37, M253, M223, M172, YAP, M35, M201).
Results and discussion. It was found that distribution of major Y-hg’s was relatively homogenous among analysed Russian and Latvian subpopulations. Only Russian subpopulation Mezen (Archangelsk district) showed the lowest frequency of the Slavic component
representing R1a haplogroup (22.5%) in comparison to other Russian (~55%) and Latvian (~40%) subpopulations. On the other hand the Fino-Ugric speaking population representing haplogroup N1c was the most common in Mezen (51%) in comparison to other Russian (~15%) and Latvian (~45%) subpopulations. Principal component analysis revealed that haplogroup N1c links Mezen with Eastern Latvian subpopulations Semigalians and Letigalians in one cluster, representing the hypothesis that the genetic history of N1c Y chromosomes in Baltic-speaking populations is distinct from that of the Uralic speakers.
Conclusion: Findings indicate that there are no significant differences in common Y-hg distribution among analysed Russian and Latvian subpopulations; however the analysis of Y-Hg genofund in Mezen indicates possible Fino-Ugric or Baltic ancestry.