Food cue-related activity in the nucleus accumbens predicts failure to resist food desires in everyday life
Monday, Oct 15, 2012, 11:00 AM -12:00 PM
*R. B. LOPEZ
, W. HOFMANN
, D. D. WAGNER
, W. M. KELLEY
, T. F. HEATHERTON
Psychological and Brain Sci., Dartmouth Col., Hanover, NH;
Univ. of Chicago Booth Sch. of Business, Chicago, IL
Prior neuroimaging studies have repeatedly shown that the nucleus accumbens (NAcc) responds strongly to appetitive food images and also predicts future weight gain. In the current study, our objective was to determine whether individual differences in NAcc responses to appetizing food cues predict who will give in to their food desires. To do so, we combined functional neuroimaging and experience sampling methods. Thirty-one female participants completed a food cue reactivity task during a functional MRI session, and then subsequently carried mobile devices for a one-week experience sampling of their desires for food. Several times a day and at random intervals, these devices signaled participants to report their desires for food and whether or not they had given in to their desires and already ate. Multiple regression analysis revealed that activity in the NAcc during exposure to appetizing food cues predicted enactment of food desires in the subsequent week. It is possible that individual differences in food specific reward signals in the NAcc make it more difficult for some people to resist their food desires, leading to more frequent enactment of their desires.
NIH Grant HL114092
[Authors]. [Abstract Title]. Program No. XXX.XX. 2012 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2012. Online.
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