Presentation Abstract

Session: MP07-Diabetes/Metabolic Syndrome
Friday, Mar 25, 2011, 5:15 PM - 7:15 PM
Presentation: MP037 - Prospective Studies of Flavonoid Intakes and Risk of Type 2 Diabetes in US Women
Location: MP037
Pres. Time: Friday, Mar 25, 2011, 5:15 PM - 7:15 PM
Category: +NPAM - Diabetes/Metabolic Syndrome
Keywords: Nutrition; Diabetes mellitus; Women's health
Author(s): Nicole M Wedick, Harvard Sch of Public Health, Boston, MA
Abstract: Objective: To evaluate whether different subclasses of flavonoid intake are associated with risk of type 2 diabetes in women.
Design: Participants were 69,870 women in the Nurses’ Health Study I (NHS I) and 88,173 women in the Nurses’ Health Study II (NHS II) aged 26 to 65 years without cardiovascular disease, diabetes, or cancer at baseline. We prospectively evaluated dietary flavonoids, including the major subclasses (i.e., flavonols, flavones, flavanones, flavan-3-ols, anthocyanins), in relation to risk for type 2 diabetes from 1984 to 2008 (for NHS I) and 1991 to 2007 (for NHS II).
Results: We documented 9,350 cases of type 2 diabetes during 2,796,055 person-years of follow-up. Women with higher levels of total flavonoid intake had a slightly lower risk of type 2 diabetes [pooled relative risk (RR): 0.91; 95% confidence interval (CI): 0.86, 0.97; p for trend = 0.026] after multivariate adjustment for age, body mass index, lifestyle and dietary factors. Higher intake of anthocyanins, but not other flavonoids, was associated with a lower risk of type 2 diabetes (RR: 0.86; CI: 0.80, 0.92; p for trend <0.001). In addition, higher intake of the anthocyanin-rich foods consumed in these cohorts (i.e., blueberries, apples or pears) was significantly associated with a lower risk of type 2 diabetes.
Conclusion: Higher intake of anthocyanins, but not other flavonoid subclasses, was associated with a lower risk for type 2 diabetes among women.
Disclosures:  N.M. Wedick: None.