Recognition of previously viewed faces in pre-symptomatic familial Alzheimer’s disease: An fMRI study
Wednesday, Nov 17, 2010, 8:00 AM - 9:00 AM
*Y. T. QUIROZ
, K. CELONE
, A. BUDSON
, A. RUIZ-RIZZO
, F. LOPERA
, C. E. STERN
Dept. of Psychology, Silvio O. Conte Ctr. For Memory and Brain, Boston Univ., Boston, MA;
Ctr. of Excellence for Learning in Education, Science, and Technology, Boston Univ., Boston, MA;
Grupo de Neurociencias, Univ. de Antioquia, Medellin, Colombia;
Boston Univ. Alzheimer's Dis. Center, Dept. of Neurology, Boston Univ. Sch. of Med., Boston, MA
There is considerable evidence that Alzheimer’s disease (AD) largely affects episodic memory. AD pathology, which begins in the preclinical stages of the disease, damages key brain structures responsible for successful recognition memory, including medial temporal lobe structures, lateral parietal cortex and prefrontal cortex. We used fMRI to examine whether early pre-symptomatic functional alterations could be observed in these regions during recognition of previously viewed faces in young cognitively-intact individuals who carry the E280A presenilin-1 (PS-1) mutation. These individuals will develop AD around the age of 45 (Lopera et al., 1997). Eight young pre-symptomatic PS-1 carriers and seven age and education matched controls (mean age = 34 yrs old) participated. During encoding, participants learned a set of 86 face-name pairs (adapted from Sperling et al. 2003). A recognition memory test followed encoding and consisted of three conditions: old faces (86 previously viewed), new faces (86 new), and fixation. Participants indicated via button press whether they recognized the face shown as old or new. fMRI BOLD scans were collected on a 1.5 T Phillips Achieva Scanner (TR=2s, TE=40, flip-angle 90°, voxel size= 3x3x6mm). Analyses focused on the recognition data. Behaviorally, there were no significant differences in accuracy or reaction time between the groups. SPM8 analyses revealed significantly increased fMRI activity for successful recognition (hits vs. correct rejections) in bilateral parietal and prefrontal cortices for both controls and pre-symptomatic PS-1 carriers. Between-group comparisons revealed that PS-1 carriers demonstrate greater activity in the right dorsolateral prefrontal cortex and left lateral parietal cortex compared to matched controls during successful recognition. We conclude that the patterns of brain activity related to successful recognition memory differ between PS-1 carriers and controls, and these differences are evident many years before the onset of clinical symptoms. Continued examination of fMRI activity differences in pre-symptomatic PS-1 carriers may lead to the identification of early preclinical markers that can be used to predict sporadic forms of Alzheimer's disease.
Boston University Center for Neuroscience
Boston University Department of Psychology
Boston University Alzheimer’s Disease Center pilot award (P30 AG13846)
[Authors]. [Abstract Title]. Program No. XXX.XX. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010. Online.
2010 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
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