Couch potatoes rejoice! Prevention of age-related bradykinesia by caloric restriction initiated at middle age
Monday, Nov 11, 2013, 8:00 AM - 9:00 AM
++C.06.b. Physiological and molecular correlates
*M. F. SALVATORE
, V. FIELDS
, J. C. ARNOLD
, J. TERREBONNE
, C. RUNFALO
, D. K. INGRAM
Dept Pharmacol, Toxicol & Neurosci, LSU Hlth. Sci. Cntr, SHREVEPORT, LA;
Nutritional Neurosci. and Aging Lab., Pennington Biomed. Res. Ctr., Baton Rouge, LA
After age 65, the risk of bradykinesia, a cardinal symptom of Parkinson’s disease, increases dramatically to an extent that 50% of those over 80 years of age will be affected. The quality of daily life is compromised due to the impairment of initiating movements necessary for navigating the environment. Because of the prevalence of this impairment, lifestyle strategies initiated in middle age could possibly reduce the risk of bradykinesia. Calorie restriction (CR) initiated in aged primate or rodents increases locomotor activity, but here, we investigated whether this nutritional intervention could prevent bradykinesia associated with aging when initiated at middle age. Specifically, we imposed a 30% CR regimen beginning at 12 mo of age in male Brown-Norway/Fischer 344 F1 hybrid rats and measured their locomotor activity every 6 weeks until 18 mo of age. Compared to their baseline activity measurements, rats that were maintained on ad libitum feeding exhibited significant declines in locomotor activity every 6 weeks for a 30% overall decline over the course of 6 months. In contrast, rats on 30% CR showed no significant decline in locomotor activity during this period. Most notably, the response to CR differed between rats having a high versus low baseline locomotor activity. Low baseline activity rats responded to CR in a shorter period of time (within 6 weeks) compared to high baseline activity rats (within 12 weeks). Furthermore, low baseline activity rats on CR actually exceeded their original baseline activity level and maintained this increase throughout the study period. High baseline activity rats eventually returned to their original 12 month baseline despite an initial decrease below it and then maintained their baseline for the duration of the CR. In summary, we note early steady decline in locomotor activity in rats maintained on ad libitum diets beginning at 12 months of age, and this decline is totally attenuated in rats maintained on 30% CR. We speculate these changes will be related to prevention of age-related loss of dopamine in the substantia nigra.
NIH Grant AG040261
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