Presentation Abstract

Title: J16.43 - Ancient mtDNA diversity in Bulgaria
Keywords: mitochondrial DNA; evolution; ancient population
Authors: D. V. Nesheva1, S. Karachanak-Yankova1, Y. Yordanov2, D. Caramelli3, M. Lari3, A. Galabov4, D. Toncheva1;
1Department of Medical genetics, Sofia, Bulgaria, 2Institute of Experimental Pathology, Morphology and Anthropology, BAS, Sofia, Bulgaria, 3Department of Biology Laboratory of Anthropology Molecular Anthropology /Paleogenetics Unit University of Florence, Italy, Florence, Italy, 4The Stephan Angeloff Institute of Microbiology, BAS;, Sofia, Bulgaria.
Abstract: Background: To understand the biological evolution of Bulgarians, we need to clarify the changes of the Bulgarian gene pool over the times. This can be achieved by describing the genetic structure of the populations that inhabited Bulgarian lands in the past and comparing it with the results obtained from the study of contemporary Bulgarians.
Results: Using the most stringent criteria for ancient DNA analysis we analyzed 122 ancient samples from different regions of Bulgaria, dating from III Millennium B.C. to VIII- X Century A.D. Preliminary results on 14 individuals (360 bp of HVS I sequence of Mitochondrial DNA) have shown that part of the ancient haplotypes are present among present-day Bulgarians, but we have also found haplotypes which are not observed in the contemporary population. Conclusion: Our results revealed discrepancies and overlaps between the ancient population and the modern Bulgarian mtDNA diversity.
Acknowledgement: This study was supported by contract [[unable to display character: №]] D[[unable to display character: О]]02-110/22 may 2009 of the Ministry of Education and Science, Bulgaria