Presentation Abstract

Session: General Poster Session 2
Abstract Number: 970-P
Title: Feasibility Assessment of the MiniMed Duo Device: Combined Insulin Delivery and Glucose Sensing
Authors: KIRSTEN N├śRGAARD, GAYANE VOSKANYAN, SUMONA ADHYA, HENRIK EGESBORG, JULIE THEANDER, PRATIK AGRAWAL, RAJIV SHAH, Hvidovre, Denmark, Northridge, CA.
Abstract: A rising number of insulin-requiring patients simultaneously use insulin pumps and continuous glucose sensors, which currently are separately inserted devices. Medtronic developed a new device (MiniMed Duo) combining a sensor and an infusion catheter on the same platform. The device improves on the Combo-set and features a steel needle for insulin infusion and an Enlite sensor platform. It is inserted with a specialized insertion device. The Minimed Duo device was tested in 20 adult (9 male) type 1 diabetes patients who were accustomed to using pumps and sensors.
Each patient wore one MiniMed Duo and one Enlite sensor (control) for 3 days. The MiniMed Duo was used for glucose signal recording and insulin delivery during 2 inpatient periods of 12 hours (7AM-7PM) on day 1 and day 3 during which subjects took 3 meals with insulin boluses and frequent blood glucose (BG) tests. The remainder of the time was spent in the outpatient setting. At the end of the study, a survey evaluating the experience with the MiniMed Duo device was given.
Two-hour postprandial BG values were measured. On day 1 and 3 of device wear (19 subjects, 114 meals), the mean 2-h postprandial BGs were 138±58.5 mg/dL and 137.8±62.1 mg/dL, respectively; the inter-day difference was not significant (P=0.9). Mean time needed for post-prandial glucose values to return to pre-prandial levels was 128±65 min. Clarke Error Grid analysis of all paired points over 3 days demonstrated comparable accuracy of MiniMed Duo (A+B, 96.38%) and Enlite sensors (A+B, 97.07%, P=0.41). Patients were generally satisfied with the overall experience (mean of 6.6±0.74 on a 7-point Likert scale).
This feasibility study demonstrated that the new combination insulin delivery-glucose sensing device can be effectively used for insulin delivery and accurate measurement of glucose. Use of the MiniMed Duo may enhance patient compliance and reduce the burden associated with diabetes management.





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