Selective optical drive of the thalamic reticular nucleus generates thalamocortical bursting and neocortical spindle oscillations
Sunday, Nov 13, 2011, 1:00 PM - 2:00 PM
*M. M. HALASSA
, J. H. SIEGLE
, J. RITT
, J. TING
, G. FENG
, C. I. MOORE
Dept. of Psychiatry, Massachusetts Gen. Hosp., Cambridge, MA;
Brain and Cognitive Sci., MIT, Cambridge, MA;
Biomed. Engin., Boston Univ., Boston, MA
Thalamocortical firing patterns regulate sensory processing and behavioral state. The thalamic reticular nucleus (TRN) is thought to influence thalamocortical firing, yet causal demonstration of this hypothesized role, and its association with behavioral state, are unknown. Using a transgenic animal with channelrhodopsin-2 expression enriched in TRN and custom implants optimized for multi-electrode recording and optical delivery in behaving mice, we found that brief drive of TRN switched thalamocortical firing mode from tonic to bursting. This selective optical drive also generated neocortical spindle oscillations, the induction of which depended strongly on behavioral state. These findings provide key causal support for the function of TRN in vivo and introduce a new model for addressing the role of this structure in behavior
[Authors]. [Abstract Title]. Program No. XXX.XX. 2011 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2011. Online.
2011 Copyright by the Society for Neuroscience all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
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