Presentation Abstract

Session: 04-Lipids and Lipoproteins
Tuesday, Mar 02, 2010, 5:00 PM - 7:00 PM
Presentation: P23 - The Effects of Aerobic Versus Resistance Exercise Training on Lipoprotein Particle Concentrations: Findings from STRRIDE-AT/RT
Location: Grand Ballroom A
Pres. Time: Tuesday, Mar 02, 2010, 5:00 PM - 7:00 PM
Category: +NPAM - Lipids & Lipoproteins
Keywords: Physical activity; Lipids; Cardiovascular disease prevention
Author(s): Mahesh J Patel, Cris A Slentz, Leslie H Willis, Lori A Bateman, Duke Univ, Durham, NC; Tamlyn A Shields, Joseph A Houmard, East Carolina Univ, Greenville, NC; William E Kraus, Duke Univ, Durham, NC
Abstract: Introduction: The beneficial effects of aerobic training (AT) on blood lipids have been proven by strong clinical studies. However, the effects of resistance training (RT) on lipids, particularly lipoprotein (LP) particle concentrations, remain largely unclear. An evaluation of the effects of AT, RT, and AT/RT on LP particles was performed in the randomized controlled trial STRRIDE-AT/RT.
Methods: Sedentary and overweight (BMI 25-35 kg/m2 ) men and women with moderate dyslipidemia (n=155), ages 18-70, completed a 4-month inactive control period before being randomized into one of three 8-month exercise programs. Of those subjects, 141 had LP particle data, completed their exercise training programs and were included in this analysis. LP particles were measured by nuclear magnetic resonance spectroscopy. The exercise training programs were: RT [3 days/wk, 3 sets/day of 8-12 repetitions on 8 different Cybex machines targeting all major muscle groups], AT [~120 min/wk at 75%VO2 max], and AT/RT [exact combination of AT and RT].
Results: At baseline, the mean total low-density lipoprotein particle concentration (LDL-P) was 1394.2 nmol/L and the mean total high-density lipoprotein particle concentration (HDL-P) was 31.4 nmol/L. By the end of the 8-month exercise programs, only subjects within the AT and AT/RT groups experienced a significant decrease in total LDL-P compared to control, and no difference was observed between the AT and AT/RT groups. (see Figure) Similar findings were observed for medium, small, and very small LDL-P subclasses. LDL-P size and HDL-P both increased significantly from baseline with aerobic exercise compared to control. The only significant effect observed in the RT group for the above lipid parameters was an increase in HDL-P from baseline compared to control.
Conclusion: AT resulted in significant improvements in LP particle concentrations, while RT resulted in very few. Lipids can be more favorably modified by AT compared to RT in a sedentary and overweight population with moderate dyslipidemia.
Disclosures:  M.J. Patel, None; C.A. Slentz, None; L.H. Willis, None; L.A. Bateman, None; T.A. Shields, None; J.A. Houmard, None; W.E. Kraus, None.